alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B

Stable Identifier
R-HSA-389963
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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alpha-tubulin:GTP:Cofactor B +Cofactor E -> alpha-tubulin:GTP: Cofactor E +Cofactor B
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The factor B:alpha tubulin complex act as a reservoir capable of accepting or delivering alpha tubulin to cofactor E (Tian et al., 1997). In the reverse reaction, cofactor B may displace cofactor E in the cofactor E:alpha tubulin complex.

Literature References
PubMed ID Title Journal Year
9265649 Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors

Tian, G, Lewis, SA, Feierbach, B, Stearns, T, Rommelaere, H, Ampe, C, Cowan, NJ

J Cell Biol 1997
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Inferred From
alpha-tubulin:GTP + Cofactor B -> alpha-tubulin:GTP: Cofactor B (Bos taurus)
Authored
Matthews, L  (2008-12-01)
Reviewed
Cowan, NJ  (2009-01-21)
Created
Matthews, L  (2009-01-22)
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