Reactome | SHP-1 and SHP-2 bind pBTLA

SHP-1 and SHP-2 bind pBTLA

Stable Identifier

R-HSA-389941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Upon BTLA activation, its phosphorylated tyrosine residues facilitate the recruitment of SH2-domain-containing phosphatases, SHP-1 and SHP-2. While the specific targets of these phosphatases in BTLA signaling are not well-defined, they are thought to play a role in dephosphorylating signaling intermediates downstream of antigen receptors in lymphocytes or potentially modulate the PI3K-AKT pathway, impacting cell survival and immune response (Watanabe et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12796776	BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 Hurchla, MA, Fallarino, F, Zimmerman, N, Sedý, JR, Gavrieli, M, Loftin, SK, Zang, X, Murphy, KM, Sim, J, Murphy, TL, Russell, JH, Allison, JP, Yang, J, Watanabe, N	Nat Immunol	2003
16932752	Balancing co-stimulation and inhibition with BTLA and HVEM Sedý, JR, Nelson, CA, Murphy, KM	Nat Rev Immunol	2006