SHP-1 and SHP-2 bind pBTLA

Stable Identifier
R-HSA-389941
Type
Reaction
Species
Homo sapiens
Compartment
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The cytoplasmic tail of BTLA contains three tyrosine residues that are conserved in most organisms. The tyrosine residues Y257 and Y282 are both present in ITIM motif sequences. These tyrosine residues are phosphorylated after BTLA cross-linking, and both ITIM motifs recruit the tyrosine phosphatases SHP1 and SHP2. The targets of SHP1 and SHP2 recruited to BTLA are not known, although it is possible that they also have a role in dephosphorylating signaling intermediates downstream of antigen receptors in lymphocytes or in specifically targeting the PI3K-AKT pathway.

Literature References
PubMed ID Title Journal Year
12796776 BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

Hurchla, MA, Fallarino, F, Zimmerman, N, Sedý, JR, Gavrieli, M, Loftin, SK, Zang, X, Murphy, KM, Sim, J, Murphy, TL, Russell, JH, Allison, JP, Yang, J, Watanabe, N

Nat Immunol 2003
16932752 Balancing co-stimulation and inhibition with BTLA and HVEM

Sedý, JR, Nelson, CA, Murphy, KM

Nat Rev Immunol 2006
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