Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-Y180-ICOS [plasma membrane]
Stable Identifier
R-HSA-389927
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phosphorylated ICOS
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
p-Y180-ICOS [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
p-Y180-ICOS [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by ICOS (Homo sapiens)
PI3K binds ICOS (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
p-Y180-ICOS [plasma membrane] (Homo sapiens)
p-Y180-ICOS [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
p-Y180-ICOS [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
p-Y180-ICOS [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6W8-1 ICOS
Gene Names
ICOS, AILIM
Other Identifiers
11731360_a_at
16889829
210439_PM_at
210439_at
2523879
2523880
2523881
2523885
2523886
2523887
2523889
29851
34607_at
8047702
GE79870
GO:0002376
GO:0002517
GO:0005515
GO:0005576
GO:0005886
GO:0006955
GO:0007155
GO:0016020
GO:0031295
GO:0098609
HMNXSV003006044
ILMN_1669927
PH_hs_0003666
TC02001202.hg
g5360718_3p_at
Participates
as an input of
PI3K binds ICOS (Homo sapiens)
as a component of
ICOS:PI3K [plasma membrane] (Homo sapiens)
Other forms of this molecule
ICOS-1 [plasma membrane]
Inferred To
phospho-Icos [plasma membrane]
(Mus musculus)
phospho-Icos [plasma membrane]
(Rattus norvegicus)
phospho-p-Y180-ICOS [plasma membrane]
(Gallus gallus)
phospho-p-Y180-ICOS [plasma membrane]
(Sus scrofa)
phospho-ICOS [plasma membrane]
(Bos taurus)
phospho-ICOS [plasma membrane]
(Canis familiaris)
phospho-icos [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 180
Coordinate
180
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_036224.1
Guide to Pharmacology - Targets
2939
ENSEMBL
ENSP00000319476
,
ENST00000316386
,
ENSP00000415951
,
ENST00000435193
OpenTargets
ENSG00000163600
HPA
ENSG00000163600-ICOS
PRO
Q9Y6W8
Pharos - Targets
Q9Y6W8
GlyGen
Q9Y6W8
Orphanet
ICOS
PDB
7JOO
,
6X4G
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75144 ICOSLG
1
ICOSLG [plasma membrane]
(R-HSA-197910)
0.733
8
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.623
5
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
TBK1 [cytosol]
(R-HSA-166267)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
p-TBK1 [cytosol]
(R-HSA-9008705)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
0.499
5
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text