Grb2 binds pBTLA

Stable Identifier
R-HSA-389919
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Grb2 binds pBTLA
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The sequence around Y226 in the BTLA cytoplasmic domain is a predicted recruitment site for Grb2. Despite the prediction there is no direct evidence of protein recruitment to this tyrosine motif.
Literature References
PubMed ID Title Journal Year
12796776 BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

Hurchla, MA, Fallarino, F, Zimmerman, N, Sedý, JR, Gavrieli, M, Loftin, SK, Zang, X, Murphy, KM, Sim, J, Murphy, TL, Russell, JH, Allison, JP, Yang, J, Watanabe, N

Nat Immunol 2003
16932752 Balancing co-stimulation and inhibition with BTLA and HVEM

Sedý, JR, Nelson, CA, Murphy, KM

Nat Rev Immunol 2006
Participants
Input
Output
Participates
as an event of
Orthologous Events
Grb2 binds pBTLA (Canis familiaris)
Grb2 binds pBTLA (Mus musculus)
Grb2 binds pBTLA (Rattus norvegicus)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-21)
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