Reactome | Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA

Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA

Stable Identifier

R-HSA-389897

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

(2R)-pristanoyl-CoA => (2S)-pristanoyl-CoA

ReviewStatus

5/5

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Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA

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Peroxisomal 2-methylacyl-CoA racemase (AMACR) catalyzes the isomerization of (2R)-pristanoyl-CoA to form (2S)-pristanoyl-CoA. The active form of the enzyme is a monomer (Schmitz et al. 1995; Amery et al. 2000; Ferdinandusse et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11060344	Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans Van Veldhoven, PP, Amery, L, Mannaerts, GP, Fransen, M, De Nys, K	J Lipid Res	2000
11060359	Subcellular localization and physiological role of alpha-methylacyl-CoA racemase IJlst, L, Denis, S, Wanders, RJA, Dacremont, G, Waterham, HR, Ferdinandusse, S	J Lipid Res	2000
7649182	Purification and characterization of an alpha-methylacyl-CoA racemase from human liver Fingerhut, R, Conzelmann, E, Albers, C, Schmitz, W	Eur J Biochem	1995