Reactome | (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)

(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)

Stable Identifier

R-HSA-389891

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

(2S)-pristanoyl-CoA + O2 => (2E)-pristenoyl-CoA + H2O2

ReviewStatus

5/5

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(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)

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Peroxisomal ACOX3 catalyzes the reaction of (2S)-pristanoyl-CoA and O2 to form trans-2,3-dehydropristanoyl-CoA and H2O2. ACOX3 protein and enzyme activity have been observed in prostate tumors, but are undetectable in normal prostate tissue as well as in liver and kidney (where ACOX2 catalyzes the oxidation of pristanoyl-CoA) (Zha et al. 2005; Vanhooren et al. 1997). The physiological consequences of this differential gene expression are unknown.

Literature References

PubMed ID	Title	Journal	Year
15599942	Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer Zha, S, Ferdinandusse, S, Hicks, JL, Denis, S, Dunn, TA, Wanders, RJA, Luo, J, De Marzo, AM, Isaacs, WB	Prostate	2005
9271077	Evidence for the existence of a pristanoyl-CoA oxidase gene in man Vanhooren, JC, Marynen, P, Mannaerts, GP, Van Veldhoven, PP	Biochem J	1997