HAO1 tetramer oxidizes glycolate to glyoxylate

Stable Identifier
R-HSA-389842
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
glycolate + O2 => glyoxylate + H2O2
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Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glycolate and O2 to form glyoxylate and H2O2. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

Literature References
PubMed ID Title Journal Year
10777549 Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases

Gould, SJ, Morrell, JC, Jones, JM

J Biol Chem 2000
18215067 Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design

Holmes, RP, Murray, MS, Lowther, WT

Biochemistry 2008
17669354 Purification and characterization of recombinant human liver glycolate oxidase

Pietrancosta, N, Rumsby, G, Vignaud, C, Lederer, F, Williams, EL

Arch Biochem Biophys 2007
10978532 Identification and expression of a cDNA for human glycolate oxidase

Rumsby, G, Cregeen, DP, Williams, EL

Biochim Biophys Acta 2000
Participants
Participates
Catalyst Activity

(S)-2-hydroxy-acid oxidase activity of HAO1 tetramer [peroxisomal matrix]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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