Reactome | HAO1 tetramer oxidizes glycolate to glyoxylate

HAO1 tetramer oxidizes glycolate to glyoxylate

Stable Identifier

R-HSA-389842

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

glycolate + O2 => glyoxylate + H2O2

ReviewStatus

5/5

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HAO1 tetramer oxidizes glycolate to glyoxylate

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Peroxisomal hydroxyacid oxidase 1 catalyzes the reaction of glycolate and O2 to form glyoxylate and H2O2. The active form of the enzyme is associated with FMN and is a tetramer (Jones et al. 2000; Murray et al. 2008; Vignaud et al. 2007; Williams et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10777549	Identification and characterization of HAOX1, HAOX2, and HAOX3, three human peroxisomal 2-hydroxy acid oxidases Jones, JM, Morrell, JC, Gould, SJ	J Biol Chem	2000
18215067	Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design Murray, MS, Holmes, RP, Lowther, WT	Biochemistry	2008
17669354	Purification and characterization of recombinant human liver glycolate oxidase Vignaud, C, Pietrancosta, N, Williams, EL, Rumsby, G, Lederer, F	Arch Biochem Biophys	2007
10978532	Identification and expression of a cDNA for human glycolate oxidase Williams, EL, Cregeen, DP, Rumsby, G	Biochim Biophys Acta	2000