Reactome | glycine + O2 => glyoxylate + H2O2 + NH4+

glycine + O2 => glyoxylate + H2O2 + NH4+

Stable Identifier

R-HSA-389821

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

glycine + H2O + O2 => glyoxylate + H2O2 + NH4(+)

ReviewStatus

5/5

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glycine + O2 => glyoxylate + H2O2 + NH4+

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Peroxisomal D-amino-acid oxidase catalyzes the reaction of glycine, water, and O2 to form glyoxylate, H2O2, and NH4+. The active form of the enzyme is a homodimer and has FAD as a cofactor (Kawazoe et al. 2006; Molla et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
17088322	Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring Kawazoe, T, Tsuge, H, Pilone, MS, Fukui, K	Protein Sci	2006
16616139	Characterization of human D-amino acid oxidase Molla, G, Sacchi, S, Bernasconi, M, Pilone, MS, Fukui, K, Polegioni, L	FEBS Lett	2006