Reactome | pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate

pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate

Stable Identifier

R-HSA-389632

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

2,6,10,14-tetramethylpentadecanoate + ATP + CoA => AMP + diphosphate + pristanoyl-CoA

ReviewStatus

5/5

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pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate

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VLCS (very long chain acyl-CoA synthetase), associated with the inner surface of the peroxisomal membrane, catalyzes the reaction of pristanate, CoA-SH and ATP to form pristanoyl-CoA, AMP and pyrophosphate (Steinberg et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9662422	Involvement of microsomal fatty aldehyde dehydrogenase in the alpha-oxidation of phytanic acid Verhoeven, NM, Carney, G, Rizzo, WB, Somers, MP, Wanders, RJ, Jakobs, C	FEBS Lett	1998
10198260	Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism Mihalik, SJ, Watkins, PA, Wang, SJ, Kim, DG, Steinberg, SJ	Biochem Biophys Res Commun	1999