ALDH3A2-2 oxidizes pristanal to pristanate

Stable Identifier
R-HSA-389609
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
pristanal + NAD+ => pristanate + NADH + H+
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Peroxisomal ALDH3A2-2 (fatty aldehyde dehydrogenase family 3 member A2, isoform 2) catalyzes the NAD-dependent dehydrogenation of pristanal to form pristanate (Jansen et al. 2001; Kelson et al. 1997; Rizzo et al. 2001). Structural studies suggest that the enzyme is a homodimer (Keller et al. 2010), and expression studies of the homologous mouse proteins in cultured cells indicate that ALDH3A2 isoform 2 is localized to peroxisomes while isoform 1 is localized to the endoplasmic reticulum (Ashibe et al. 2007).

Literature References
PubMed ID Title Journal Year
17510064 Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing

Ashibe, B, Hirai, T, Higashi, K, Sekimizu, K, Motojima, K

J. Biol. Chem. 2007
11341778 Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes

Jansen, GA, van den Brink, DM, Ofman, R, Draghici, O, Dacremont, G

Biochem Biophys Res Commun 2001
19965611 Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal

Keller, MA, Watschinger, K, Golderer, G, Maglione, M, Sarg, B, Lindner, HH, Werner-Felmayer, G, Terrinoni, A, Wanders, RJ, Werner, ER

J. Lipid Res. 2010
11306053 Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren-Larsson syndrome

Rizzo, WB, Lin, Z, Carney, G

Chem. Biol. Interact. 2001
9133646 Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

Kelson, TL, Secor McVoy, JR, Rizzo, WB

Biochim. Biophys. Acta 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aldehyde dehydrogenase (NAD+) activity of ALDH3A2-2 dimer [peroxisomal membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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