Reactome | ALDH3A2-2 oxidizes pristanal to pristanate

ALDH3A2-2 oxidizes pristanal to pristanate

Stable Identifier

R-HSA-389609

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

pristanal + NAD+ => pristanate + NADH + H+, 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH

ReviewStatus

5/5

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ALDH3A2-2 oxidizes pristanal to pristanate

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Peroxisomal ALDH3A2-2 (fatty aldehyde dehydrogenase family 3 member A2, isoform 2) catalyzes the NAD-dependent dehydrogenation of pristanal to form pristanate (Jansen et al. 2001; Kelson et al. 1997; Rizzo et al. 2001). Structural studies suggest that the enzyme is a homodimer (Keller et al. 2010), and expression studies of the homologous mouse proteins in cultured cells indicate that ALDH3A2 isoform 2 is localized to peroxisomes while isoform 1 is localized to the endoplasmic reticulum (Ashibe et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
11341778	Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes Jansen, GA, van den Brink, DM, Ofman, R, Draghici, O, Dacremont, G	Biochem Biophys Res Commun	2001
17510064	Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing Ashibe, B, Hirai, T, Higashi, K, Sekimizu, K, Motojima, K	J. Biol. Chem.	2007
19965611	Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal Keller, MA, Watschinger, K, Golderer, G, Maglione, M, Sarg, B, Lindner, HH, Werner-Felmayer, G, Terrinoni, A, Wanders, RJA, Werner, ER	J. Lipid Res.	2010
11306053	Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren-Larsson syndrome Rizzo, WB, Lin, Z, Carney, G	Chem. Biol. Interact.	2001
9133646	Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization Kelson, TL, Secor McVoy, JR, Rizzo, WB	Biochim. Biophys. Acta	1997