ALDH3A2-2 oxidizes pristanal to pristanate

Stable Identifier
Reaction [transition]
Homo sapiens
pristanal + NAD+ => pristanate + NADH + H+
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Peroxisomal ALDH3A2-2 (fatty aldehyde dehydrogenase family 3 member A2, isoform 2) catalyzes the NAD-dependent dehydrogenation of pristanal to form pristanate (Jansen et al. 2001; Kelson et al. 1997; Rizzo et al. 2001). Structural studies suggest that the enzyme is a homodimer (Keller et al. 2010), and expression studies of the homologous mouse proteins in cultured cells indicate that ALDH3A2 isoform 2 is localized to peroxisomes while isoform 1 is localized to the endoplasmic reticulum (Ashibe et al. 2007).

Literature References
PubMed ID Title Journal Year
11341778 Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes

Jansen, GA, Dacremont, G, Draghici, O, Ofman, R, van den Brink, DM

Biochem Biophys Res Commun 2001
17510064 Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing

Hirai, T, Ashibe, B, Motojima, K, Higashi, K, Sekimizu, K

J. Biol. Chem. 2007
19965611 Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal

Lindner, HH, Werner-Felmayer, G, Werner, ER, Golderer, G, Keller, MA, Maglione, M, Wanders, RJA, Sarg, B, Terrinoni, A, Watschinger, K

J. Lipid Res. 2010
11306053 Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren-Larsson syndrome

Lin, Z, Rizzo, WB, Carney, G

Chem. Biol. Interact. 2001
9133646 Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization

Rizzo, WB, Secor McVoy, JR, Kelson, TL

Biochim. Biophys. Acta 1997
Catalyst Activity

aldehyde dehydrogenase (NAD+) activity of ALDH3A2-2 dimer [peroxisomal membrane]

Orthologous Events
Cross References
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