Reactome | ALDH3A2-2 oxidizes pristanal to pristanate

ALDH3A2-2 oxidizes pristanal to pristanate

Stable Identifier

R-HSA-389609

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

pristanal + NAD+ => pristanate + NADH + H+, 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) => 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH

ReviewStatus

5/5

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ALDH3A2-2 oxidizes pristanal to pristanate

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Peroxisomal ALDH3A2-2 (fatty aldehyde dehydrogenase family 3 member A2, isoform 2) catalyzes the NAD-dependent dehydrogenation of pristanal to form pristanate (Jansen et al. 2001; Kelson et al. 1997; Rizzo et al. 2001). Structural studies suggest that the enzyme is a homodimer (Keller et al. 2010), and expression studies of the homologous mouse proteins in cultured cells indicate that ALDH3A2 isoform 2 is localized to peroxisomes while isoform 1 is localized to the endoplasmic reticulum (Ashibe et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
11341778	Identification of pristanal dehydrogenase activity in peroxisomes: conclusive evidence that the complete phytanic acid alpha-oxidation pathway is localized in peroxisomes Jansen, GA, Dacremont, G, Draghici, O, Ofman, R, van den Brink, DM	Biochem Biophys Res Commun	2001
17510064	Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing Hirai, T, Ashibe, B, Motojima, K, Higashi, K, Sekimizu, K	J. Biol. Chem.	2007
19965611	Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal Lindner, HH, Werner-Felmayer, G, Werner, ER, Golderer, G, Keller, MA, Maglione, M, Wanders, RJA, Sarg, B, Terrinoni, A, Watschinger, K	J. Lipid Res.	2010
11306053	Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren-Larsson syndrome Lin, Z, Rizzo, WB, Carney, G	Chem. Biol. Interact.	2001
9133646	Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization Rizzo, WB, Secor McVoy, JR, Kelson, TL	Biochim. Biophys. Acta	1997