PP2A binds CTLA4 dimer

Stable Identifier
R-HSA-389532
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Newly synthesized CTLA4 expressed on the transmembrane associates with PP2A, and under these conditions the inhibitory function of CTLA4 is inactive. CTLA4 homodimer has a PP2A trimer bound to each tail. The A subunit of PP2A binds the lysine-rich motif located at lysine residues 152, 155, and 156 of the juxtamembrane region of the CTLA-4 tail, and the C subunit binds the Y165 residue.
Literature References
PubMed ID Title Journal Year
16551244 A molecular perspective of CTLA-4 function

Madrenas, J, Teft, WA, Kirchhof, MG

Annu Rev Immunol 2006
12876557 Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

Schneider, H, Rudd, CE

Nat Rev Immunol 2003
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