PP2A binds CTLA4 dimer

Stable Identifier
R-HSA-389532
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PP2A binds CTLA4 dimer
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Newly synthesized CTLA4 expressed on the transmembrane associates with PP2A, and under these conditions the inhibitory function of CTLA4 is inactive. CTLA4 homodimer has a PP2A trimer bound to each tail. The A subunit of PP2A binds the lysine-rich motif located at lysine residues 152, 155, and 156 of the juxtamembrane region of the CTLA-4 tail, and the C subunit binds the Y165 residue.

Literature References
PubMed ID Title Journal Year
16551244 A molecular perspective of CTLA-4 function

Madrenas, J, Teft, WA, Kirchhof, MG

Annu Rev Immunol 2006
12876557 Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

Schneider, H, Rudd, CE

Nat Rev Immunol 2003
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Orthologous Events
PP2A binds CTLA4 dimer (Bos taurus)
PP2A binds CTLA4 dimer (Canis familiaris)
PP2A binds CTLA4 dimer (Danio rerio)
PP2A binds CTLA4 dimer (Mus musculus)
PP2A binds CTLA4 dimer (Rattus norvegicus)
PP2A binds CTLA4 dimer (Sus scrofa)
PP2A binds CTLA4 dimer (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-08)
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