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PP2A binds CTLA4 dimer
Stable Identifier
R-HSA-389532
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CTLA4 inhibitory signaling (Homo sapiens)
PP2A binds CTLA4 dimer (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Newly synthesized CTLA4 expressed on the transmembrane associates with PP2A, and under these conditions the inhibitory function of CTLA4 is inactive. CTLA4 homodimer has a PP2A trimer bound to each tail. The A subunit of PP2A binds the lysine-rich motif located at lysine residues 152, 155, and 156 of the juxtamembrane region of the CTLA-4 tail, and the C subunit binds the Y165 residue.
Literature References
PubMed ID
Title
Journal
Year
16551244
A molecular perspective of CTLA-4 function
Madrenas, J
,
Teft, WA
,
Kirchhof, MG
Annu Rev Immunol
2006
12876557
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling
Schneider, H
,
Rudd, CE
Nat Rev Immunol
2003
Participants
Input
CTLA4 dimer [plasma membrane]
(Homo sapiens)
PP2A [cytosol]
(Homo sapiens)
Output
CTLA4 dimer:PP2A [plasma membrane]
(Homo sapiens)
Participates
as an event of
CTLA4 inhibitory signaling (Homo sapiens)
Orthologous Events
PP2A binds CTLA4 dimer (Bos taurus)
PP2A binds CTLA4 dimer (Canis familiaris)
PP2A binds CTLA4 dimer (Mus musculus)
PP2A binds CTLA4 dimer (Rattus norvegicus)
PP2A binds CTLA4 dimer (Sus scrofa)
Authored
Garapati, P V (2008-12-16)
Reviewed
Bluestone, JA (2009-06-01)
Esensten, J (2009-06-01)
Created
Garapati, P V (2009-01-08)
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