BTLA interacts with HVEM

Stable Identifier
R-HSA-389523
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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BTLA interacts with HVEM
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The B and T lymphocyte attenuator, BTLA, is one of the co-inhibitory receptors of CD28 superfamily along with CTLA-4 and PD-1. BTLA differs from other CD28 members by having an extracellular Ig C-like domain, instead of a V-like one. Herpesvirus entry mediator (HVEM) is the external ligand for BTLA, providing the first example of a functional interaction between a TNFR and an Ig superfamily member. Binding of HVEM to BTLA delivers an inhibitory signal to T cells.

Literature References
PubMed ID Title Journal Year
16932752 Balancing co-stimulation and inhibition with BTLA and HVEM

Murphy, KM, Nelson, CA, Sedý, JR

Nat Rev Immunol 2006
15568026 B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

Sedy, JR, Gavrieli, M, Potter, KG, Hurchla, MA, Lindsley, RC, Hildner, K, Scheu, S, Pfeffer, K, Ware, CF, Murphy, TL, Murphy, KM

Nat. Immunol. 2005
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Orthologous Events
BTLA interacts with HVEM (Canis familiaris)
BTLA interacts with HVEM (Mus musculus)
BTLA interacts with HVEM (Rattus norvegicus)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2009-01-08)