The B and T lymphocyte attenuator, BTLA, is one of the co-inhibitory receptors of CD28 superfamily along with CTLA-4 and PD-1. BTLA differs from other CD28 members by having an extracellular Ig C-like domain, instead of a V-like one. Herpesvirus entry mediator (HVEM) is the external ligand for BTLA, providing the first example of a functional interaction between a TNFR and an Ig superfamily member. Binding of HVEM to BTLA delivers an inhibitory signal to T cells.
Murphy, KM, Nelson, CA, Sedý, JR
Sedy, JR, Gavrieli, M, Potter, KG, Hurchla, MA, Lindsley, RC, Hildner, K, Scheu, S, Pfeffer, K, Ware, CF, Murphy, TL, Murphy, KM
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