Reactome | BTLA interacts with HVEM

BTLA interacts with HVEM

Stable Identifier

R-HSA-389523

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor belonging to the CD28 superfamily, alongside CTLA-4 and PD-1. Unlike other members of the CD28 family, BTLA possesses an extracellular Ig C-like domain rather than a V-like domain. Its ligand, the Herpesvirus entry mediator (HVEM), represents the first known example of a functional interaction between a TNF receptor (TNFR) family member and an Ig superfamily member. The binding of HVEM to BTLA delivers an inhibitory signal to T cells, playing a crucial role in regulating immune responses and maintaining immune homeostasis (Murphy et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
15568026	B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator Sedy, JR, Gavrieli, M, Potter, KG, Hurchla, MA, Lindsley, RC, Hildner, K, Scheu, S, Pfeffer, K, Ware, CF, Murphy, TL, Murphy, KM	Nat. Immunol.	2005
16932752	Balancing co-stimulation and inhibition with BTLA and HVEM Murphy, KM, Nelson, CA, Sedý, JR	Nat Rev Immunol	2006