Reactome | Two NPFF receptors can bind neuropeptide FF

Two NPFF receptors can bind neuropeptide FF

Stable Identifier

R-HSA-389491

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Orexin and neuropeptides FF and QRFP bind to their respective receptors (Homo sapiens)
        
        Two NPFF receptors can bind neuropeptide FF (Homo sapiens)

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Two NPFF receptors can bind neuropeptide FF

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The 8 residue neuropeptide FF (NPFF, morphine-modulating peptide) (Perry SJ et al, 1997) is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors bind NPFF; NPFF1 and NPFF2 (Bonini JA et al, 2000). These receptors share the highest amino acid sequence homology with members of the orexin, NPY, and cholecystokinin families, which have been implicated in feeding. This may be a potential role for NPFF1/2. These receptors mediate the action of NPFF by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Literature References

PubMed ID	Title	Journal	Year
11024015	Identification and characterization of two G protein-coupled receptors for neuropeptide FF Bonini, JA, Jones, KA, Adham, N, Forray, C, Artymyshyn, R, Durkin, MM, Smith, KE, Tamm, JA, Boteju, LW, Lakhlani, PP, Raddatz, R, Yao, WJ, Ogozalek, KL, Boyle, N, Kouranova, EV, Quan, Y, Vaysse, PJ, Wetzel, JM, Branchek, TA, Gerald, C, Borowsky, B	J Biol Chem	2000
9224703	A human gene encoding morphine modulating peptides related to NPFF and FMRFamide Perry, SJ, Yi-Kung Huang, E, Cronk, D, Bagust, J, Sharma, R, Walker, RJ, Wilson, S, Burke, JF	FEBS Lett	1997