Two NPFF receptors can bind neuropeptide FF

Stable Identifier
Reaction [binding]
Homo sapiens
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The 8 residue neuropeptide FF (NPFF, morphine-modulating peptide) (Perry SJ et al, 1997) is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors bind NPFF; NPFF1 and NPFF2 (Bonini JA et al, 2000). These receptors share the highest amino acid sequence homology with members of the orexin, NPY, and cholecystokinin families, which have been implicated in feeding. This may be a potential role for NPFF1/2. These receptors mediate the action of NPFF by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Literature References
PubMed ID Title Journal Year
11024015 Identification and characterization of two G protein-coupled receptors for neuropeptide FF

Quan, Y, Wetzel, JM, Forray, C, Bonini, JA, Jones, KA, Branchek, TA, Borowsky, B, Yao, WJ, Tamm, JA, Artymyshyn, R, Smith, KE, Boyle, N, Gerald, C, Ogozalek, KL, Boteju, LW, Raddatz, R, Adham, N, Vaysse, PJ, Durkin, MM, Lakhlani, PP, Kouranova, EV

J Biol Chem 2000
9224703 A human gene encoding morphine modulating peptides related to NPFF and FMRFamide

Sharma, R, Cronk, D, Wilson, S, Walker, RJ, Burke, JF, Bagust, J, Yi-Kung Huang, E, Perry, SJ

FEBS Lett 1997
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