Orexin 2 receptor can bind orexin-B neuropeptide

Stable Identifier
Reaction [binding]
Homo sapiens
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The orexin (hypocretin) neuropeptides (A and B) both derive from a 131 residue precursor, prepro-orexin peptide (Sakurai T et al, 1999). Orexin B (Lee JH et al, 1999) binds preferentially to the orphan GPCR orexin 2 receptor (Sakurai T et al, 1998). This activated complex can transduce its signal via the Gq class of G protein. Orexin deficiency is inferred in narcolepsy and regulation of feeding behaviour.

Literature References
PubMed ID Title Journal Year
10364220 Structure and function of human prepro-orexin gene

Sakurai, T, Yanagisawa, M, Nakamura, T, Moriguchi, T, Goto, K, Kajiwara, N, Furuya, K

J Biol Chem 1999
9491897 Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Chemelli, RM, Terrett, JA, Haynes, AC, Elshourbagy, NA, Sakurai, T, Matsuzaki, I, Amemiya, A, Yanagisawa, M, Buckingham, RE, Kozlowski, GP, Bergsma, DJ, Liu, WS, Carr, SA, Richardson, JA, Ishii, M, Williams, SC, Wilson, S, Annan, RS, McNulty, DE, Tanaka, H, Arch, JR

Cell 1998
10583376 Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B

Chae, KJ, Lee, W, Lee, DW, Lee, JH, Bang, E, Kim, JY

Eur J Biochem 1999
Orthologous Events
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