Proteinase-activated receptors can bind thrombin

Stable Identifier
R-HSA-389463
Type
Reaction [binding]
Species
Homo sapiens
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Thrombin (Butkowski RJ et al, 1977) plays a vital role in blood homeostasis, inflammation and wound healing. Thrombin (which cleaves bonds after arginine and lysine) converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII. Complexed with thrombomodulin it can also activate protein C. It performs these functions by binding to four proteinase-activated receptors (PAR1-4) (Kahn ML, et al, 1999; Bohm SK et al, 1996). These complexes couple to G proteins which stimulate phosphoinositide hydrolysis.

Literature References
PubMed ID Title Journal Year
10079109 Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

Kahn, ML, Nakanishi-Matsui, M, Shapiro, MJ, Ishihara, H, Coughlin, SR

J Clin Invest 1999
8615752 Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

Bohm, SK, Kong, W, Bromme, D, Smeekens, SP, Anderson, DC, Connolly, A, Kahn, M, Nelken, NA, Coughlin, SR, Payan, DG, Bunnett, NW

Biochem J 1996
873923 Primary structure of human prethrombin 2 and alpha-thrombin

Butkowski, RJ, Elion, J, Downing, MR, Mann, KG

J Biol Chem 1977
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