Proteinase-activated receptors can bind thrombin

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Thrombin (Butkowski RJ et al, 1977) plays a vital role in blood homeostasis, inflammation and wound healing. Thrombin (which cleaves bonds after arginine and lysine) converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII. Complexed with thrombomodulin it can also activate protein C. It performs these functions by binding to four proteinase-activated receptors (PAR1-4) (Kahn ML, et al, 1999; Bohm SK et al, 1996). These complexes couple to G proteins which stimulate phosphoinositide hydrolysis.

Literature References
PubMed ID Title Journal Year
8615752 Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

Bunnett, NW, Smeekens, SP, Bromme, D, Kahn, M, Bohm, SK, Nelken, NA, Kong, W, Connolly, A, Coughlin, SR, Payan, DG, Anderson, DC

Biochem J 1996
10079109 Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

Shapiro, MJ, Ishihara, H, Kahn, ML, Coughlin, SR, Nakanishi-Matsui, M

J Clin Invest 1999
873923 Primary structure of human prethrombin 2 and alpha-thrombin

Butkowski, RJ, Downing, MR, Elion, J, Mann, KG

J Biol Chem 1977
Orthologous Events
Cite Us!