Reactome | ARID1A [nucleoplasm]

ARID1A [nucleoplasm]

Stable Identifier

R-HSA-389259

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BAF250a

Locations in the PathwayBrowser for interactor UniProt:Q4VC05 BCL7A

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        Positive Regulation of CDH1 Gene Transcription (Homo sapiens)
        
        ARID1A binds CDH1 gene promoter (Homo sapiens)
        
        ARID1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14497 ARID1A

Gene Names

ARID1A, BAF250, BAF250A, C1orf4, OSA1, SMARCF1

Chain

initiator methionine:, chain:2-2285

Reference Genes

BioGPS Gene:8289 ARID1A

COSMIC (genes):ARID1A ARID1A

CTD Gene:8289 ARID1A

dbSNP Gene:8289 ARID1A

ENSEMBL:ENSG00000117713 ARID1A

HGNC:11110 ARID1A

KEGG:hsa:8289 ARID1A

Monarch:8289 ARID1A

NCBI Gene:8289 ARID1A

OMIM:603024 ARID1A

UCSC:O14497 ARID1A

Reference Transcript

Participates

as an input of

as a component of

as a member of

ARID1A,B [nucleoplasm] (Homo sapiens)

as a candidate of

SWI/SNF additional components [nucleoplasm] (Homo sapiens)

Inferred To

Arid1a [nucleoplasm] (Mus musculus)

Arid1a [nucleoplasm] (Rattus norvegicus)

ARID1A [nucleoplasm] (Bos taurus)

ARID1A [nucleoplasm] (Canis familiaris)

ARID1A [nucleoplasm] (Sus scrofa)

Ghost homologue of ARID1A [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of ARID1A [nucleoplasm] (Gallus gallus)

Ghost homologue of ARID1A [nucleoplasm] (Xenopus tropicalis)

osa [nucleoplasm] (Drosophila melanogaster)

let-526 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_006006.3, NP_624361.1

OpenTargets

ENSG00000117713

ENSEMBL

ENSP00000387636, ENSP00000320485, ENSP00000363267, ENST00000457599, ENST00000324856, ENSG00000117713, ENST00000374152

HPA

ENSG00000117713-ARID1A

GeneCards

ARID1A

PRO

O14497

Pharos - Targets

O14497

Orphanet

ARID1A

GlyGen

O14497

PDB

1RYU, 6LTJ, 6LTH

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.942	28
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.864	18
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.837	9
UniProt:Q92922 SMARCC1	1	SMARCC1 [nucleoplasm] (R-HSA-389257)	0.788	8
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.788	12
UniProt:Q8TAQ2 SMARCC2	1	SMARCC2 [nucleoplasm] (R-HSA-389263)	0.788	9
UniProt:Q15532 SS18	1	SS18 [nucleoplasm] (R-HSA-9727441)	0.758	9
UniProt:P51531 SMARCA2	1	SMARCA2 [nucleoplasm] (R-HSA-389256)	0.757	6
UniProt:Q92785 DPF2	1	DPF2 [nucleoplasm] (R-HSA-9727509)	0.725	7
UniProt:Q92925 SMARCD2	1	SMARCD2 [nucleoplasm] (R-HSA-5225626)	0.669	6
UniProt:Q8WUZ0 BCL7C	1	BCL7C [nucleoplasm] (R-HSA-9727457)	0.643	5
UniProt:Q4VC05 BCL7A	1	BCL7A [nucleoplasm] (R-HSA-9727449)	0.643	4
UniProt:Q6STE5 SMARCD3	1	SMARCD3 [nucleoplasm] (R-HSA-400141)	0.643	3
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.615	3
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.527	4
UniProt:Q92784 DPF3	1	DPF3 [nucleoplasm] (R-HSA-9727469)	0.527	3
UniProt:Q92782 DPF1	1	DPF1 [nucleoplasm] (R-HSA-8855001)	0.527	2
UniProt:Q14526 HIC1	2	monoSUMO1-K333-HIC1 [nucleoplasm] (R-HSA-4090368) HIC1 [nucleoplasm] (R-HSA-4090364)	0.508	2
UniProt:P50553 ASCL1	1	ASCL1 [nucleoplasm] (R-HSA-212402)	0.499	2
UniProt:Q9UHA2 S18L2			0.483	3
UniProt:A4PIV7 A4PIV7			0.462	5

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