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RBL1 [nucleoplasm]
Stable Identifier
R-HSA-389104
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p107, p107 (RBL1)
Locations in the PathwayBrowser for interactor UniProt:Q9Y463 DYR1B
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)
RBL1 [nucleoplasm] (Homo sapiens)
p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)
RBL1 [nucleoplasm] (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)
RBL1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28749 RBL1
Gene Names
RBL1
Chain
chain:1-1068
Reference Genes
BioGPS Gene:5933 RBL1
COSMIC (genes):RBL1 RBL1
CTD Gene:5933 RBL1
dbSNP Gene:5933 RBL1
ENSEMBL:ENSG00000080839 RBL1
ENSEMBL_homo_sapiens_GENE:ENSG00000080839.12 RBL1
HGNC:9893 RBL1
KEGG Gene (Homo sapiens):5933 RBL1
Monarch:5933 RBL1
NCBI Gene:5933 RBL1
OMIM:116957 RBL1
UCSC:P28749 RBL1
Reference Transcript
RefSeq:NM_002895.4 RBL1
RefSeq:NM_183404.3 RBL1
Other Identifiers
11738630_a_at
11740382_at
11740383_at
1555003_PM_at
1555003_at
1555004_PM_a_at
1555004_a_at
1559307_PM_s_at
1559307_s_at
16919044
1907_at
205296_PM_at
205296_at
3904748
3904749
3904750
3904752
3904753
3904754
3904756
3904760
3904763
3904766
3904768
3904769
3904770
3904771
3904772
3904774
3904775
3904776
3904777
3904778
3904779
3904780
3904782
3904783
3904784
3904785
3904786
3904787
3904792
3904793
3904794
5933
77729_r_at
8066136
A_23_P28733
A_24_P276102
GE81207
GO:0000122
GO:0000278
GO:0000785
GO:0000977
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0007049
GO:0010629
GO:0030154
GO:0043226
GO:0043550
GO:0051726
GO:1990841
GO:2000134
GO:2000773
HMNXSV003012951
HMNXSV003042054
Hs.87.0.S2_3p_x_at
Hs2.406930.1.S1_3p_s_at
Hs2.87.2.S1_3p_at
Hs2.87.2.S1_3p_s_at
ILMN_1753013
ILMN_1782745
L14812_at
PH_hs_0000013
TC20000822.hg
Participates
as an output of
Dephosphorylation of p107 (RBL1) by PP2A (Homo sapiens)
RBL1 gene expression is repressed by the DREAM complex (Homo sapiens)
as a component of
RBL1:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
RBL1:E2F4:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
RBL1:E2F4/5:DP1/2 [nucleoplasm] (Homo sapiens)
as an input of
p107 (RBL1) binds CyclinE/A:CDK2 (Homo sapiens)
as a candidate of
RBL1,RBL2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
Inferred To
RBL1 [nucleoplasm]
(Bos taurus)
RBL1 [nucleoplasm]
(Canis familiaris)
RBL1 [nucleoplasm]
(Gallus gallus)
RBL1 [nucleoplasm]
(Sus scrofa)
lin-35 [nucleoplasm]
(Caenorhabditis elegans)
rbl1 [nucleoplasm]
(Danio rerio)
rbl1 [nucleoplasm]
(Xenopus tropicalis)
Rbl1 [nucleoplasm]
(Mus musculus)
Rbl1 [nucleoplasm]
(Rattus norvegicus)
Homologues of RBL1 [nucleoplasm]
(Drosophila melanogaster)
Rbf [nucleoplasm]
(Drosophila melanogaster)
rblA [nucleoplasm]
(Dictyostelium discoideum)
Rbf2 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002886.2
,
NP_899662.1
OpenTargets
ENSG00000080839
GeneCards
P28749
HPA
ENSG00000080839-RBL1
Ensembl
ENST00000373664
,
ENSP00000343646
,
ENSG00000080839
,
ENSP00000362768
,
ENST00000344359
PRO
P28749
Pharos - Targets
P28749
PDB
5TUV
,
7SMD
,
4YOS
,
1H28
,
4YOO
,
4YOZ
,
7SMC
,
7SMF
,
7SME
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.837
9
UniProt:P03129 VE7
0.825
5
UniProt:P06788 VE7
0.737
4
UniProt:Q9Y463 DYR1B
0.67
4
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.67
4
UniProt:P03255 E1A
0.591
3
UniProt:Q01094 E2F1
2
E2F1 [nucleoplasm]
(R-HSA-68639)
p-E2F1 [nucleoplasm]
(R-HSA-187911)
0.564
2
UniProt:P06430 VE7
0.547
2
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.544
2
UniProt:Q6ZUJ4 CC062
0.527
2
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.527
2
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.527
4
UniProt:Q13574-2 DGKZ
0.524
2
UniProt:Q923E4 Sirt1
2
Sirt1 [nucleoplasm]
(R-MMU-5211238)
SIRT1 [nucleoplasm]
(R-MMU-427531)
0.524
2
UniProt:P24610
1
Pax3 [nucleoplasm]
(R-MMU-5603237)
0.524
3
UniProt:Q9BUH8 BEGAIN
1
BEGAIN [cytosol]
(R-HSA-6794250)
0.508
2
UniProt:O43524 FOXO3
11
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
FOXO3 [cytosol]
(R-HSA-5687032)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841824)
Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix]
(R-HSA-9841849)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
FOXO3 [nucleoplasm]
(R-HSA-199305)
0.499
3
UniProt:Q14653 IRF3
6
p-5S,T404-IRF3 [nucleoplasm]
(R-HSA-936418)
p-4S,T404-IRF3 [nucleoplasm]
(R-HSA-177654)
p-4S,T404-IRF3 [cytosol]
(R-HSA-166258)
IRF3(272-427) [cytosol]
(R-HSA-9729737)
IRF3(2-271) [cytosol]
(R-HSA-9729696)
IRF3 [cytosol]
(R-HSA-166251)
0.499
2
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