Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RBL2 [nucleoplasm]
Stable Identifier
R-HSA-389102
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p130, p130 (RBL2)
Locations in the PathwayBrowser for interactor UniProt:Q9Y463 DYR1B
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)
RBL2 [nucleoplasm] (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
RBL2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of cell cycle genes (Homo sapiens)
RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
RBL2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08999 RBL2
Gene Names
RBL2, RB2
Chain
chain:1-1139
Reference Genes
BioGPS Gene:5934 RBL2
COSMIC (genes):RBL2 RBL2
CTD Gene:5934 RBL2
dbSNP Gene:5934 RBL2
ENSEMBL:ENSG00000103479 RBL2
ENSEMBL_homo_sapiens_GENE:ENSG00000103479.17 RBL2
HGNC:9894 RBL2
KEGG Gene (Homo sapiens):5934 RBL2
Monarch:5934 RBL2
NCBI Gene:5934 RBL2
OMIM:180203 RBL2
UCSC:Q08999 RBL2
Reference Transcript
RefSeq:NM_005611.3 RBL2
RefSeq:NM_001323608.1 RBL2
Other Identifiers
11718165_a_at
11718166_a_at
11747866_a_at
11748255_a_at
16818980
1986_at
212331_PM_at
212331_at
212332_PM_at
212332_at
32597_at
3661066
3661067
3661070
3661071
3661073
3661075
3661076
3661077
3661079
3661082
3661083
3661084
3661085
3661087
3661089
3661090
3661092
3661093
3661094
3661096
3661098
3661099
3661100
3661101
3661102
3661107
3661108
3661109
3661110
3661111
5934
7995631
A_14_P123504
A_14_P131886
A_23_P26413
A_24_P416159
GE60009
GO:0000278
GO:0000785
GO:0000977
GO:0003677
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005829
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0007049
GO:0010629
GO:0030154
GO:0043226
GO:0043550
GO:0051726
GO:0070062
GO:1990841
GO:2000134
HMNXSV003049133
Hs.79362.0.S1_3p_at
Hs.79362.0.S3_3p_at
ILMN_1756999
PH_hs_0023465
TC16000448.hg
X76061_at
Participates
as an output of
RBL2 gene expression is stimulated by FOXO1,FOXO3,FOXO4 (Homo sapiens)
Dephosphorylation of p130 (RBL2) by PP2A (Homo sapiens)
as a component of
RBL2:Cyclin E/A:CDK2 [nucleoplasm] (Homo sapiens)
RBL2:E2F4,E2F5:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
as an input of
p130 (RBL2) binds Cyclin E/A:CDK2 (Homo sapiens)
as a member of
RBL1,RBL2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T401,S672,S1035-RBL2 [nucleoplasm]
Inferred To
Rbl2 [nucleoplasm]
(Mus musculus)
Rbl2 [nucleoplasm]
(Rattus norvegicus)
lin-35 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of RBL2 [nucleoplasm]
(Danio rerio)
Rbf [nucleoplasm]
(Drosophila melanogaster)
rblA [nucleoplasm]
(Dictyostelium discoideum)
RBL2 [nucleoplasm]
(Bos taurus)
RBL2 [nucleoplasm]
(Canis familiaris)
RBL2 [nucleoplasm]
(Gallus gallus)
RBL2 [nucleoplasm]
(Sus scrofa)
rbl2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001310537.1
,
NP_005602.3
OpenTargets
ENSG00000103479
HPA
ENSG00000103479-RBL2
GeneCards
Q08999
Ensembl
ENSG00000103479
,
ENST00000262133
,
ENSP00000262133
PRO
Q08999
Pharos - Targets
Q08999
PDB
4XI9
,
5C1D
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.892
10
UniProt:Q16254 E2F4
1
E2F4 [nucleoplasm]
(R-HSA-68664)
0.748
8
UniProt:Q5TKA1 LIN9
1
LIN9 [nucleoplasm]
(R-HSA-389108)
0.702
13
UniProt:Q96GY3 LIN37
1
LIN37 [nucleoplasm]
(R-HSA-389101)
0.702
13
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.69
7
UniProt:P03129 VE7
0.659
3
UniProt:Q6MZP7 LIN54
1
LIN54 [nucleoplasm]
(R-HSA-389103)
0.623
10
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.597
5
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.597
4
UniProt:Q61412 VSX2
0.593
4
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.59
2
UniProt:P24610
1
Pax3 [nucleoplasm]
(R-MMU-5603237)
0.581
3
UniProt:Q52LA3 LIN52
2
p-S28-LIN52 [nucleoplasm]
(R-HSA-1362251)
LIN52 [nucleoplasm]
(R-HSA-389107)
0.558
7
UniProt:Q99708-2 RBBP8
0.556
3
UniProt:I6L8A6 I6L8A6
0.556
3
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.544
2
UniProt:P13631 RARG
1
RARG [nucleoplasm]
(R-HSA-446161)
0.527
2
UniProt:P30279 CCND2
2
CCND2 [cytosol]
(R-HSA-68340)
CCND2 [nucleoplasm]
(R-HSA-113827)
0.527
2
UniProt:Q9Y463 DYR1B
0.527
2
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.527
3
UniProt:Q923E4 Sirt1
2
Sirt1 [nucleoplasm]
(R-MMU-5211238)
SIRT1 [nucleoplasm]
(R-MMU-427531)
0.524
2
UniProt:Q13574-2 DGKZ
0.524
2
UniProt:P03255 E1A
0.524
2
UniProt:Q99708 RBBP8
4
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
RBBP8 [nucleoplasm]
(R-HSA-912399)
Ac-K-RBBP8 [nucleoplasm]
(R-HSA-5685955)
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
0.508
2
UniProt:O96020 CCNE2
3
Unfolded CCNE2 [cytosol]
(R-HSA-6813844)
CCNE2 [cytosol]
(R-HSA-157452)
CCNE2 [nucleoplasm]
(R-HSA-68367)
0.462
3
UniProt:Q15329 E2F5
1
E2F5 [nucleoplasm]
(R-HSA-68669)
0.462
4
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.462
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text