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NTSR1 [plasma membrane]
Stable Identifier
R-HSA-388916
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Neurotensin receptor type 1; Short=NT-R-1; AltName: Full=High-affinity levocabastine-insensitive neurotensin receptor; AltName: Full=NTRH; GN Name=NTSR1; Synonyms=NTRR; OS Homo sapiens, NTR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Neurotensin receptors can bind neurotensins (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR1 [plasma membrane] (Homo sapiens)
NTSR1,NTSR2:NTS(151-163) [plasma membrane] (Homo sapiens)
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
NTSR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30989 NTSR1
Gene Names
NTSR1, NTRR
Chain
chain:1-418
Reference Genes
BioGPS Gene:4923 NTSR1
COSMIC (genes):NTSR1 NTSR1
CTD Gene:4923 NTSR1
dbSNP Gene:4923 NTSR1
ENSEMBL:ENSG00000101188 NTSR1
HGNC:8039 NTSR1
KEGG:hsa:4923 NTSR1
Monarch:4923 NTSR1
NCBI Gene:4923 NTSR1
OMIM:162651 NTSR1
UCSC:P30989 NTSR1
Reference Transcript
RefSeq:NM_002531.2 NTSR1
Other Identifiers
11733521_at
16915740
207360_PM_s_at
207360_s_at
35080_at
3892874
3892875
3892882
3892883
3892885
3892886
3892887
3892888
3892889
3892890
3892891
3892892
3892893
3892894
3892896
3892898
4923
8063942
A_14_P131233
A_24_P378806
GE482827
GO:0001659
GO:0003085
GO:0003254
GO:0004930
GO:0005515
GO:0005783
GO:0005794
GO:0005886
GO:0007186
GO:0007218
GO:0007268
GO:0007612
GO:0008344
GO:0009898
GO:0009986
GO:0010628
GO:0014049
GO:0014054
GO:0016020
GO:0016492
GO:0023052
GO:0030424
GO:0030425
GO:0032280
GO:0033993
GO:0042802
GO:0043025
GO:0043065
GO:0043066
GO:0043195
GO:0043197
GO:0043198
GO:0043204
GO:0043226
GO:0043576
GO:0043679
GO:0044309
GO:0044877
GO:0045121
GO:0050877
GO:0050965
GO:0051280
GO:0051281
GO:0055085
GO:0060089
GO:0060732
GO:0070779
GO:0071545
GO:0090238
GO:0097151
GO:0098712
HMNXSV003052429
ILMN_1778831
PH_hs_0006090
TC20000495.hg
X70070_at
Participates
as a member of
NTSR1,NTSR2 [plasma membrane] (Homo sapiens)
Inferred To
NTSR1 [plasma membrane]
(Bos taurus)
NTSR1 [plasma membrane]
(Canis familiaris)
NTSR1 [plasma membrane]
(Gallus gallus)
NTSR1 [plasma membrane]
(Sus scrofa)
PK2-R1 [plasma membrane]
(Drosophila melanogaster)
nmur-1 [plasma membrane]
(Caenorhabditis elegans)
nmur-2 [plasma membrane]
(Caenorhabditis elegans)
sphr-1 [plasma membrane]
(Caenorhabditis elegans)
ntsr1 [plasma membrane]
(Danio rerio)
npr-20 [plasma membrane]
(Caenorhabditis elegans)
Ntsr1 [plasma membrane]
(Mus musculus)
Ntsr1 [plasma membrane]
(Rattus norvegicus)
PK1-R [plasma membrane]
(Drosophila melanogaster)
CapaR [plasma membrane]
(Drosophila melanogaster)
Homologues of NTSR1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of NTSR1 [plasma membrane]
(Drosophila melanogaster)
PK2-R2 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002522.2
Guide to Pharmacology - Targets
309
ENSEMBL
ENST00000370501
,
ENSP00000359532
OpenTargets
ENSG00000101188
ZINC - Substances
NTR1_HUMAN
ZINC - Biogenic
NTR1_HUMAN
ZINC target
P30989
PRO
P30989
GlyGen
P30989
PDB
8JPB
,
8JPF
,
6OS9
,
8JPC
,
6UP7
,
6PWC
,
2LYW
,
6OSA
,
7UL2
ZINC - Investigational
NTR1_HUMAN
HPA
ENSG00000101188-NTSR1
Pharos - Targets
P30989
ZINC - Predictions - Purchasable
NTR1_HUMAN
HMDB Protein
HMDBP07853
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30990 NTS
3
NTS(151-160) [extracellular region]
(R-HSA-8940947)
NTS(161-163) [extracellular region]
(R-HSA-8940954)
NTS(151-163) [extracellular region]
(R-HSA-388915)
0.558
2
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