Neurotensin receptors can bind neurotensins

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R-HSA-388900
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Reaction [binding]
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Homo sapiens
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Neurotensin (Dong Z et al, 1998) is a 13-amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release. It also has significant interaction with the dopaminergic system. Neurotensin is synthesized as part of a precursor protein that also contains the related neuropeptide neuromedin N. The neurotensin receptor binds neurotensin. There are two transmembrane receptors encoded by the NTSR1 (Vita N et al, 1993) and NTSR2 (Vita N et al, 1998) genes.

Literature References
PubMed ID Title Journal Year
9530155 DNA methylation contributes to expression of the human neurotensin/neuromedin N gene

Wang, X, Evers, BM, Dong, Z, Zhao, Q, Townsend CM, Jr

Am J Physiol 1998
9851594 Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells

Soubrie, P, Caput, D, Bachy, A, Keane, P, Le Fur, G, Vita, N, Guillemot, M, Casellas, P, Maffrand, JP, Ferrara, P, Kaghad, M, Oury-Donat, F, Thurneyssen, O, Poinot-Chazel, C, Chalon, P, Garcia, S

Eur J Pharmacol 1998
8381365 Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor

Le Fur, G, Laurent, P, Vita, N, Gully, D, Caput, D, Lefort, S, Ferrara, P, Kaghad, M, Dumont, X, Chalon, P

FEBS Lett 1993
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