Reactome | Neurotensin receptors can bind neurotensins

Neurotensin receptors can bind neurotensins

Stable Identifier

R-HSA-388900

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Neurotensin receptors can bind neurotensins

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Neurotensin (Dong Z et al, 1998) is a 13-amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release. It also has significant interaction with the dopaminergic system. Neurotensin is synthesized as part of a precursor protein that also contains the related neuropeptide neuromedin N. The neurotensin receptor binds neurotensin. There are two transmembrane receptors encoded by the NTSR1 (Vita N et al, 1993) and NTSR2 (Vita N et al, 1998) genes.

Literature References

PubMed ID	Title	Journal	Year
9530155	DNA methylation contributes to expression of the human neurotensin/neuromedin N gene Wang, X, Evers, BM, Dong, Z, Zhao, Q, Townsend CM, Jr	Am J Physiol	1998
9851594	Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells Soubrie, P, Caput, D, Bachy, A, Keane, P, Le Fur, G, Vita, N, Guillemot, M, Casellas, P, Maffrand, JP, Ferrara, P, Kaghad, M, Oury-Donat, F, Thurneyssen, O, Poinot-Chazel, C, Chalon, P, Garcia, S	Eur J Pharmacol	1998
8381365	Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor Le Fur, G, Laurent, P, Vita, N, Gully, D, Caput, D, Lefort, S, Ferrara, P, Kaghad, M, Dumont, X, Chalon, P	FEBS Lett	1993