Reactome | Neurotensin receptors can bind neurotensins

Neurotensin receptors can bind neurotensins

Stable Identifier

R-HSA-388900

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Neurotensin receptors can bind neurotensins

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Neurotensin (Dong Z et al, 1998) is a 13-amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release. It also has significant interaction with the dopaminergic system. Neurotensin is synthesized as part of a precursor protein that also contains the related neuropeptide neuromedin N. The neurotensin receptor binds neurotensin. There are two transmembrane receptors encoded by the NTSR1 (Vita N et al, 1993) and NTSR2 (Vita N et al, 1998) genes.

Literature References

PubMed ID	Title	Journal	Year
9530155	DNA methylation contributes to expression of the human neurotensin/neuromedin N gene Dong, Z, Wang, X, Zhao, Q, Townsend CM, Jr, Evers, BM	Am J Physiol	1998
9851594	Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells Vita, N, Oury-Donat, F, Chalon, P, Guillemot, M, Kaghad, M, Bachy, A, Thurneyssen, O, Garcia, S, Poinot-Chazel, C, Casellas, P, Keane, P, Le Fur, G, Maffrand, JP, Soubrie, P, Caput, D, Ferrara, P	Eur J Pharmacol	1998
8381365	Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor Vita, N, Laurent, P, Lefort, S, Chalon, P, Dumont, X, Kaghad, M, Gully, D, Le Fur, G, Ferrara, P, Caput, D	FEBS Lett	1993