Reactome | NPY1R [plasma membrane]

NPY1R [plasma membrane]

Stable Identifier

R-HSA-388896

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Neuropeptide Y receptor type 1; AltName: Full=NPY1-R;
GN Name=NPY1R; Synonyms=NPYR, NPYY1;
OS Homo sapiens, NPY1R_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY1R [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY1R [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY1R [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY1R [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY1R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P25929 NPY1R

Gene Names

NPY1R, NPYR, NPYY1

Chain

chain:1-384

Reference Genes

BioGPS Gene:4886 NPY1R

COSMIC (genes):NPY1R NPY1R

CTD Gene:4886 NPY1R

dbSNP Gene:4886 NPY1R

ENSEMBL:ENSG00000164128 NPY1R

HGNC:7956 NPY1R

KEGG:hsa:4886 NPY1R

Monarch:4886 NPY1R

NCBI Gene:4886 NPY1R

OMIM:162641 NPY1R

UCSC:P25929 NPY1R

Reference Transcript

Other Identifiers

11727386_a_at

11727387_s_at

11751576_a_at

16981099

205440_PM_s_at

205440_s_at

2792128

2792129

2792130

2792131

2792132

2792133

2792134

2792138

2792139

2792140

2792141

2792145

35437_at

4886

8103494

90580_at

GE58241

GO:0001601

GO:0001602

GO:0003151

GO:0004930

GO:0004983

GO:0005515

GO:0005886

GO:0005975

GO:0006006

GO:0007186

GO:0007187

GO:0007193

GO:0007218

GO:0007626

GO:0007631

GO:0008188

GO:0008217

GO:0016020

GO:0019233

GO:0040014

GO:0042923

GO:0043005

GO:0050877

GO:0060089

HMNXSV003016082

ILMN_1667947

L07615_at

M88461_s_at

PH_hs_0030764

TC04001698.hg

g4505444_3p_s_at

Participates

as a member of

Neuropeptide Y receptors [plasma membrane] (Homo sapiens)

Inferred To

npy1r [plasma membrane] (Danio rerio)

npy1r [plasma membrane] (Xenopus tropicalis)

Npy1r [plasma membrane] (Mus musculus)

Npy1r [plasma membrane] (Rattus norvegicus)

NPY1R [plasma membrane] (Bos taurus)

NPY1R [plasma membrane] (Canis familiaris)

NPY1R [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_000900.1, XP_011530312.1, XP_005263088.1

Guide to Pharmacology - Targets

305

ENSEMBL

ENSG00000164128, ENST00000296533, ENSP00000354652

OpenTargets

ENSG00000164128

ZINC - Substances

NPY1R_HUMAN

ZINC target

P25929

PRO

P25929

GlyGen

P25929

PDB

7X9A, 8K6O, 8K6M, 7VGX, 5ZBQ

ZINC - Investigational

NPY1R_HUMAN

GeneCards

NPY1R

HPA

ENSG00000164128-NPY1R

Pharos - Targets

P25929

ZINC - Predictions - Purchasable

NPY1R_HUMAN

HMDB Protein

HMDBP13635