Reactome | PPY(30-65) [extracellular region]

PPY(30-65) [extracellular region]

Stable Identifier

R-HSA-388882

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Pancreatic peptide, RecName: Full=Pancreatic prohormone; AltName: Full=Pancreatic polypeptide; Short=PP; AltName: INN=Obinepitide; Contains: RecName: Full=Pancreatic hormone; Short=PH; Contains: RecName: Full=Pancreatic icosapeptide; Short=PI; Flags: Precursor;
GN Name=PPY; Synonyms=PNP;
OS Homo sapiens, PAHO_HUMAN, PPY

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PPY(30-65) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PPY(30-65) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PPY(30-65) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PPY(30-65) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PPY(30-65) [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gi [extracellular region] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PPY(30-65) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PPY(30-65) [extracellular region] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PPY(30-65) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01298 PPY

Gene Names

PPY, PNP

Chain

signal peptide:1-29, peptide:30-65, peptide:69-88, propeptide:89-95

Reference Genes

BioGPS Gene:5539 PPY

COSMIC (genes):PPY PPY

CTD Gene:5539 PPY

dbSNP Gene:5539 PPY

ENSEMBL:ENSG00000108849 PNP

ENSEMBL_homo_sapiens_GENE:ENSG00000108849 PPY

HGNC:9327 PPY

KEGG Gene (Homo sapiens):5539 PPY

Monarch:5539 PPY

NCBI Gene:5539 PPY

OMIM:167780 PPY

UCSC:P01298 PPY

Reference Transcript

RefSeq:NM_002722.4 PPY

Other Identifiers

0001400372

11730869_s_at

11746062_s_at

16735

16845504

1TZ4

1TZ5

210670_at

32122

32339_at

3758766

3758767

3758769

3758771

3758772

5539

8015884

AAA60156

AAA60161

AAH32225

AAH40033

AC007993

BC032225

BC040033

BP385720

CAA25161

CAB016735

CCDS11472

ENSG00000108849

ENSP00000225992

ENSP00000466009

ENST00000225992

ENST00000225992.7

ENST00000591228

ENST00000591228.4

EntrezGene:5539

g190301_3p_at

GE86963

GO:0001664

GO:0003674

GO:0005179

GO:0005184

GO:0005575

GO:0005576

GO:0005615

GO:0005737

GO:0006810

GO:0007165

GO:0007186

GO:0007218

GO:0008150

GO:0009306

GO:0010469

HGNC:9327

HPA032122

ILMN_1751445

IPR001955

IPR015480

IPR020392

K7EKP2

K7EML0

M11726

M11726_at

M15788

MIM:167780

NM_001319209

NM_002722

NP_001306138

NP_002713

PF00159

PPY

PPY-201

PPY-205

PR00278

SM00309

TC17001567.hg

UPI0000001C93

X00491

XM_011524978

XP_011523280

Participant Of

hasMember

NPY receptor ligands [extracellular region]

Inferred To

Homologues of PPY(30-65) [extracellular region] (Danio rerio)

PPY(30-65) [extracellular region] (Canis familiaris)

PPY(30-65) [extracellular region] (Danio rerio)

PPY(30-65) [extracellular region] (Mus musculus)

PPY(30-65) [extracellular region] (Rattus norvegicus)

PPY(30-65) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_002713.1

OpenTargets

ENSG00000108849

GeneCards

P01298

PRO

P01298

PDB

1TZ4, 1TZ5