Reactome | PYY(29-64) [extracellular region]

PYY(29-64) [extracellular region]

Stable Identifier

R-HSA-388878

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Peptide YY, RecName: Full=Peptide YY; Short=PYY; AltName: Full=PYY-I; AltName: Full=Peptide tyrosine tyrosine; Contains: RecName: Full=Peptide YY, PYY_HUMAN, PYY

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PYY(29-64) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PYY(29-64) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PYY(29-64) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PYY(29-64) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PYY(29-64) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PYY(29-64) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PYY(29-64) [extracellular region] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        NPY receptor ligands [extracellular region] (Homo sapiens)
        
        PYY(29-64) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10082 PYY

Gene Names

PYY

Chain

signal peptide:1-28, peptide:29-64, peptide:31-64, propeptide:68-97

Reference Genes

BioGPS Gene:5697 PYY

COSMIC (genes):PYY PYY

CTD Gene:5697 PYY

dbSNP Gene:5697 PYY

ENSEMBL:ENSG00000131096 PYY

HGNC:9748 PYY

KEGG:hsa:5697 PYY

Monarch:5697 PYY

NCBI Gene:5697 PYY

OMIM:600781 PYY

UCSC:P10082 PYY

Reference Transcript

Other Identifiers

11732094_a_at

11761921_x_at

16845510

207080_3p_s_at

207080_PM_s_at

207080_s_at

211253_PM_x_at

36449_s_at

3758776

3758777

3758778

3758779

3758780

3758782

3758783

3758784

3758785

3758787

5697

8015890

A_23_P4112

A_33_P3329958

D13897_rna2_at

GE79064

GO:0001664

GO:0005179

GO:0005184

GO:0005515

GO:0005576

GO:0005615

GO:0007218

GO:0007631

GO:0030154

GO:0031841

GO:0048018

GO:0060575

GO:0098772

HMNXSV003039028

ILMN_1703075

PH_hs_0031967

TC17001568.hg

g391728_3p_a_at

g4758981_3p_a_at

g4758981_3p_x_at

Participates

as a member of

NPY receptor ligands [extracellular region] (Homo sapiens)

Inferred To

pyya [extracellular region] (Danio rerio)

Pyy [extracellular region] (Mus musculus)

Pyy [extracellular region] (Rattus norvegicus)

PYY [extracellular region] (Bos taurus)

PYY [extracellular region] (Canis familiaris)

PYY [extracellular region] (Gallus gallus)

PYY [extracellular region] (Sus scrofa)

Cross References

RefSeq

XP_011523337.1, NP_004151.3

ENSEMBL

ENSP00000467310, ENST00000692052, ENSP00000353198, ENST00000360085, ENST00000592796, ENSP00000509262

OpenTargets

ENSG00000131096

HPA

ENSG00000131096-PYY

PRO

P10082

Pharos - Targets

P10082

PDB

2DF0, 7YON, 2L60, 2NA5, 7RT9, 2DEZ