Reactome | PPYR1 [plasma membrane]

PPYR1 [plasma membrane]

Stable Identifier

R-HSA-388868

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

NYP4R, RecName: Full=Neuropeptide Y receptor type 4; Short=NPY4-R; AltName: Full=Pancreatic polypeptide receptor 1; Short=PP1;
GN Name=PPYR1; Synonyms=NPY4R;
OS Homo sapiens, NPY4R_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        PPYR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        PPYR1 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        PPYR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        PPYR1 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        PPYR1 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        PPYR1 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        PPYR1 [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        PPYR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50391 NPY4R

Gene Names

NPY4R, PPYR1

Chain

chain:1-375

Reference Genes

BioGPS Gene:100996758 NPY4R

BioGPS Gene:5540 NPY4R

COSMIC (genes):NPY4R NPY4R

CTD Gene:100996758 NPY4R

CTD Gene:5540 NPY4R

dbSNP Gene:100996758 NPY4R

dbSNP Gene:5540 NPY4R

ENSEMBL:ENSG00000204174 NPY4R

HGNC:9329 NPY4R

KEGG:hsa:100996758 NPY4R

KEGG:hsa:5540 NPY4R

Monarch:100996758 NPY4R

Monarch:5540 NPY4R

NCBI Gene:100996758 NPY4R

NCBI Gene:5540 NPY4R

OMIM:601790 NPY4R

UCSC:P50391 NPY4R

Reference Transcript

Other Identifiers

11752589_a_at

16704464

210956_PM_at

210956_at

3245029

3245031

3245032

3245033

3245034

34597_at

4037990

4037991

4037992

4037993

5540

7927280

GE59154

GO:0001602

GO:0004930

GO:0004983

GO:0005886

GO:0007154

GO:0007165

GO:0007186

GO:0007218

GO:0016020

GO:0017046

GO:0023052

GO:0042923

GO:0043005

HMNXSV003001454

ILMN_1652137

PH_hs_0027011

PH_hs_0028908

TC10000302.hg

U42387_at

g1314327_3p_at

Participates

as a member of

Neuropeptide Y receptors [plasma membrane] (Homo sapiens)

Inferred To

npy8ar [plasma membrane] (Danio rerio)

Npy4r [plasma membrane] (Mus musculus)

Npy4r [plasma membrane] (Rattus norvegicus)

PPYR1 [plasma membrane] (Bos taurus)

npy4r [plasma membrane] (Xenopus tropicalis)

NPY4R [plasma membrane] (Canis familiaris)

NPY4R [plasma membrane] (Gallus gallus)

NPY Y4 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_016854963.1, XP_016854962.1, NP_001265723.1, XP_006717608.1, XP_005277701.1, XP_011547675.1, XP_054222212.1, XP_011538239.1, XP_011547676.1, XP_016870953.1, XP_011547677.1, XP_016871875.1, XP_054222213.1, XP_016871876.1, XP_016870952.1, XP_011547678.1, XP_011538238.1, NP_001265724.1, XP_054222211.1, XP_011537416.1, XP_011537417.1, NP_005963.4

Guide to Pharmacology - Targets

307

OpenTargets

ENSG00000204174

ENSEMBL

ENSP00000480883, ENST00000612632, ENST00000374312, ENSG00000204174, ENSP00000363431

ZINC - Substances

NPY4R_HUMAN

ZINC target

P50391

PRO

P50391

GlyGen

P50391

PDB

7X9C

ZINC - Investigational

NPY4R_HUMAN

HPA

ENSG00000204174-NPY4R

GeneCards

NPY4R

Pharos - Targets

P50391

ZINC - Predictions - Purchasable

NPY4R_HUMAN

HMDB Protein

HMDBP13630