Reactome | NPY5R [plasma membrane]

NPY5R [plasma membrane]

Stable Identifier

R-HSA-388854

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Neuropeptide Y receptor type 5; Short=NPY5-R; AltName: Full=NPY-Y5 receptor; Short=Y5 receptor; AltName: Full=NPYY5;
GN Name=NPY5R; Synonyms=NPYR5;
OS Homo sapiens, NPY5R_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY5R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY5R [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY5R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY5R [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY5R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY5R [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Neuropeptide Y receptors can bind neuropeptide Y-related peptides (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY5R [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] (Homo sapiens)
        
        Neuropeptide Y receptors [plasma membrane] (Homo sapiens)
        
        NPY5R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15761 NPY5R

Gene Names

NPY5R, NPYR5

Chain

chain:1-445

Reference Genes

BioGPS Gene:4889 NPY5R

COSMIC (genes):NPY5R NPY5R

CTD Gene:4889 NPY5R

dbSNP Gene:4889 NPY5R

ENSEMBL:ENSG00000164129 NPY5R

ENSEMBL_homo_sapiens_GENE:ENSG00000164129.12 NPY5R

HGNC:7958 NPY5R

KEGG Gene (Homo sapiens):4889 NPY5R

Monarch:4889 NPY5R

NCBI Gene:4889 NPY5R

OMIM:602001 NPY5R

UCSC:Q15761 NPY5R

Reference Transcript

Other Identifiers

11752925_s_at

16972076

207400_PM_at

207400_at

2750200

2750201

2750202

2750203

2750204

2750205

2750206

2750207

2750208

2750209

2750210

33100_at

4889

8098146

A_23_P251836

A_24_P320124

GE59582

GO:0001601

GO:0001602

GO:0002376

GO:0002675

GO:0002865

GO:0003151

GO:0003214

GO:0004930

GO:0004983

GO:0005886

GO:0006954

GO:0007165

GO:0007186

GO:0007218

GO:0007268

GO:0008284

GO:0012501

GO:0014050

GO:0016020

GO:0022414

GO:0023052

GO:0032229

GO:0042755

GO:0042923

GO:0043005

GO:0043066

GO:0048661

GO:0048856

GO:0060089

GO:0060112

GO:0070374

GO:0098793

GO:0098982

GO:0099538

HMNXSV003020985

HMNXSV003022495

ILMN_1718198

ILMN_2047914

PH_hs_0027897

TC04000818.hg

U94320_at

g5453795_3p_at

Participates

as a member of

Neuropeptide Y receptors [plasma membrane] (Homo sapiens)

Inferred To

Npy5r [plasma membrane] (Mus musculus)

Npy5r [plasma membrane] (Rattus norvegicus)

NPY5R [plasma membrane] (Bos taurus)

NPY5R [plasma membrane] (Canis familiaris)

NPY5R [plasma membrane] (Gallus gallus)

NPY5R [plasma membrane] (Sus scrofa)

Homologues of NPY5R [plasma membrane] (Danio rerio)

npy5r [plasma membrane] (Xenopus tropicalis)

npyrya [plasma membrane] (Danio rerio)

NPYRYC [plasma membrane] (Danio rerio)

npyryb [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001304020.1, XP_011530319.1, NP_001304021.1, XP_005263095.1, NP_006165.1

Guide to Pharmacology - Targets

308

OpenTargets

ENSG00000164129

ZINC - Substances

NPY5R_HUMAN

ZINC target

Q15761

PRO

Q15761

ZINC - Investigational

NPY5R_HUMAN

HPA

ENSG00000164129-NPY5R

GeneCards

Q15761

Ensembl

ENST00000338566, ENSG00000164129, ENST00000506953, ENSP00000423917, ENSP00000423474, ENSP00000339377, ENST00000515560

Pharos - Targets

Q15761

ZINC - Predictions - Purchasable

NPY5R_HUMAN

HMDB Protein

HMDBP13638