Reactome | PI3K binds CD28

PI3K binds CD28

Stable Identifier

R-HSA-388832

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The phosphorylated YMNM motif in CD28 interacts with the Src homology 2 (SH2) domain of the p85 regulatory subunit of PI3K, leading to the activation of the p110 catalytic subunit. P110alpha and p110beta are broadly expressed in most cell types, whereas p110γgamma and p110delta expression is more limited to cells of the immune system. This activation allows PI3K to generate 3′-phosphoinositides, such as PIP3, which serve as docking sites for various signaling proteins containing pleckstrin homology (PH) domains (pages et al. 1994, Appleman et al. 2002, Vanhaesebroeck et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
8621607	Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association Pagès, F, Couez, D, Olive, D, Klasen, S, Sweet, R, Ward, SG, Truneh, A, Battifora, M, Ragueneau, M	J Biol Chem	1996
12670391	The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 Kane, LP, Weiss, A	Immunol Rev	2003