PI3K binds CD28

Stable Identifier
R-HSA-388832
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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PI3K binds CD28
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PI3K inducibly associates with CD28: the SH2 domains of the PI3K p85 adaptor subunit interact with a cytoplasmic YMNM consensus motif at residues 173-176 of CD28.

Literature References
PubMed ID Title Journal Year
12670391 The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3

Kane, LP, Weiss, A

Immunol Rev 2003
8621607 Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association

Pagès, F, Ragueneau, M, Klasen, S, Battifora, M, Couez, D, Sweet, R, Truneh, A, Ward, SG, Olive, D

J Biol Chem 1996
Participants
Input
Output
Participant Of
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Orthologous Events
PI3K binds CD28 (Canis familiaris)
PI3K binds CD28 (Mus musculus)
PI3K binds CD28 (Rattus norvegicus)
PI3K binds CD28 (Sus scrofa)
PI3K binds CD28 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)