SHP2 phosphatase binds CTLA-4

Stable Identifier
R-HSA-388829
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SHP2 phosphatase binds CTLA-4
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CTLA4 associates with the SH2 domain containing tyrosine phosphatase SHP2 and this interaction is mediated through the YVKM motif of CTLA-4. Phosphorylation of tyrosine in the YVKM motif recruits SHP-2.
Still the association of SHP-2 with CTLA-4 is unclear and remains controversial. Several other studies have reported that CTLA-4 does not directly associate with SHP-2. The interaction between the phosphatase and CTLA-4 may be an indirect event, possibly mediated by PI3-kinase/SHP-2 binding.
Literature References
PubMed ID Title Journal Year
9712716 Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152)

Nakaseko, C, Yamamoto, T, Miyatake, S, Umemori, H, Saito, T

Biochem Biophys Res Commun 1998
10694513 Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition

Schneider, H, Rudd, CE

Biochem Biophys Res Commun 2000
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Orthologous Events
SHP2 phosphatase binds CTLA-4 (Bos taurus)
SHP2 phosphatase binds CTLA-4 (Canis familiaris)
SHP2 phosphatase binds CTLA-4 (Gallus gallus)
SHP2 phosphatase binds CTLA-4 (Mus musculus)
SHP2 phosphatase binds CTLA-4 (Rattus norvegicus)
SHP2 phosphatase binds CTLA-4 (Sus scrofa)
SHP2 phosphatase binds CTLA-4 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)
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