Reactome | SHP2 phosphatase binds CTLA-4

SHP2 phosphatase binds CTLA-4

Stable Identifier

R-HSA-388829

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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CTLA4 associates with the SH2 domain containing tyrosine phosphatase SHP2 and this interaction is mediated through the YVKM motif of CTLA-4. Phosphorylation of tyrosine in the YVKM motif recruits SHP-2.
Still the association of SHP-2 with CTLA-4 is unclear and remains controversial. Several other studies have reported that CTLA-4 does not directly associate with SHP-2. The interaction between the phosphatase and CTLA-4 may be an indirect event, possibly mediated by PI3-kinase/SHP-2 binding.

Literature References

PubMed ID	Title	Journal	Year
10694513	Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition Schneider, H, Rudd, CE	Biochem Biophys Res Commun	2000
9712716	Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152) Miyatake, S, Nakaseko, C, Umemori, H, Yamamoto, T, Saito, T	Biochem Biophys Res Commun	1998