Grb2 binds CD28

Stable Identifier
R-HSA-388814
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Grb2 binds CD28
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CD28 is capable of binding the Src homology 3 (SH3) domains of several proteins, including Grb2. The phospho-YMNM motif in CD28's cytoplasmic domain facilitates tandem SH2–SH3 domain binding. Grb-2 has been shown to bind to the CD28 YMNM motif with additional SH3 domain binding to the diproline motif in the C-terminal portion of the cytoplasmic domain of CD28.

Literature References
PubMed ID Title Journal Year
7737275 T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

Schneider, H, Cai, YC, Prasad, KV, Shoelson, SE, Rudd, CE

Eur J Immunol 1995
9694876 Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction

Okkenhaug, K, Rottapel, R

J Biol Chem 1998
Participants
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Orthologous Events
Grb2 binds CD28 (Canis familiaris)
Grb2 binds CD28 (Mus musculus)
Grb2 binds CD28 (Rattus norvegicus)
Grb2 binds CD28 (Sus scrofa)
Grb2 binds CD28 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)