CD28 is capable of binding the Src homology 3 (SH3) domains of several proteins, including Grb2. The phospho-YMNM motif in CD28's cytoplasmic domain facilitates tandem SH2–SH3 domain binding. Grb-2 has been shown to bind to the CD28 YMNM motif with additional SH3 domain binding to the diproline motif in the C-terminal portion of the cytoplasmic domain of CD28.
Schneider, H, Cai, YC, Prasad, KV, Shoelson, SE, Rudd, CE
Okkenhaug, K, Rottapel, R
© 2021 Reactome
