Grb2 binds CD28

Stable Identifier
R-HSA-388814
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Grb2 binds CD28
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CD28 is capable of binding the Src homology 3 (SH3) domains of several proteins, including Grb2. The phospho-YMNM motif in CD28's cytoplasmic domain facilitates tandem SH2–SH3 domain binding. Grb-2 has been shown to bind to the CD28 YMNM motif with additional SH3 domain binding to the diproline motif in the C-terminal portion of the cytoplasmic domain of CD28.
Literature References
PubMed ID Title Journal Year
9694876 Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction

Rottapel, R, Okkenhaug, K

J Biol Chem 1998
7737275 T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

Prasad, KV, Shoelson, SE, Cai, YC, Schneider, H, Rudd, CE

Eur J Immunol 1995
Participants
Input
Output
Participates
as an event of
Orthologous Events
Grb2 binds CD28 (Bos taurus)
Grb2 binds CD28 (Canis familiaris)
Grb2 binds CD28 (Gallus gallus)
Grb2 binds CD28 (Mus musculus)
Grb2 binds CD28 (Rattus norvegicus)
Grb2 binds CD28 (Sus scrofa)
Grb2 binds CD28 (Xenopus tropicalis)
Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)
Cite Us!