Grb2 binds CD28

Stable Identifier
R-HSA-388814
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Grb2 binds CD28
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CD28 binds to several signaling proteins, including Grb2, through its Src homology domains. The phosphorylated YMNM motif in CD28's cytoplasmic tail primarily interacts with Grb2's SH2 domain, while the SH3 domain of Grb2 simultaneously engages a diproline motif in the C-terminal region of CD28. This dual binding mechanism enhances the stability of the CD28-Grb2 interaction, facilitating downstream signaling events that are crucial for T cell activation and cytokine production (Okkenhaug and Rottapel 1998).
Literature References
PubMed ID Title Journal Year
9694876 Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction

Rottapel, R, Okkenhaug, K

J Biol Chem 1998
7737275 T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

Prasad, KV, Shoelson, SE, Cai, YC, Schneider, H, Rudd, CE

Eur J Immunol 1995
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Orthologous Events
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Authored
Garapati, P V  (2008-12-16)
Reviewed
Bluestone, JA  (2009-06-01)
Esensten, J  (2009-06-01)
Created
Garapati, P V  (2008-12-16)
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