Reactome | MC1R [plasma membrane]

MC1R [plasma membrane]

Stable Identifier

R-HSA-388614

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

RecName: Full=Melanocyte-stimulating hormone receptor; Short=MSH-R; AltName: Full=Melanotropin receptor; AltName: Full=Melanocortin receptor 1; AltName: Full=MC1-R;
GN Name=MC1R; Synonyms=MSHR;
OS Homo sapiens, MSHR_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
    - p-S133-CREB1 binds MITF promoter (Homo sapiens)
      - MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Melanocortin receptors bind melanocortins (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC1R [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01726 MC1R

Gene Names

MC1R, MSHR

Chain

chain:1-317

Reference Genes

BioGPS Gene:4157 MC1R

COSMIC (genes):MC1R MC1R

CTD Gene:4157 MC1R

dbSNP Gene:4157 MC1R

ENSEMBL:ENSG00000258839 MC1R

ENSEMBL_homo_sapiens_GENE:ENSG00000258839.4 MC1R

HGNC:6929 MC1R

KEGG Gene (Homo sapiens):4157 MC1R

Monarch:4157 MC1R

NCBI Gene:4157 MC1R

OMIM:155555 MC1R

Reference Transcript

RefSeq:NM_002386.3 MC1R

Other Identifiers

11726028_a_at

16822150

205458_PM_at

205458_at

34557_at

3674502

3674505

3674506

3674507

3674508

3674509

3674510

3674511

4157

54532_at

7998055

A_14_P121369

A_23_P329271

A_23_P66095

A_33_P3318642

GE59938

GO:0004930

GO:0004977

GO:0004980

GO:0005515

GO:0005737

GO:0005886

GO:0006281

GO:0006351

GO:0006355

GO:0007165

GO:0007186

GO:0007187

GO:0007189

GO:0008528

GO:0009650

GO:0010739

GO:0016020

GO:0019222

GO:0019233

GO:0023052

GO:0031625

GO:0032720

GO:0035556

GO:0042438

GO:0042562

GO:0043473

GO:0045944

GO:0050877

GO:0060089

GO:0060259

GO:0070914

GO:0090037

GO:2000253

HMNXSV003020277

HMNXSV003029648

Hs.301240.0.S2_3p_at

Hs.301240.0.S2_3p_x_at

ILMN_1653319

PH_hs_0020397

X67594_at

p25993

Participates

as a member of

Melanocortin receptors [plasma membrane] (Homo sapiens)

Inferred To

mc1r [plasma membrane] (Xenopus tropicalis)

MC1R [plasma membrane] (Bos taurus)

MC1R [plasma membrane] (Danio rerio)

MC1R [plasma membrane] (Gallus gallus)

MC1R [plasma membrane] (Sus scrofa)

Mc1r [plasma membrane] (Mus musculus)

Mc1r [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_002377.4

Guide to Pharmacology - Targets

282

OpenTargets

ENSG00000258839

ZINC - Substances

MSHR_HUMAN

ZINC target

Q01726

PRO

Q01726

PDB

7F4D, 7F4F, 7F4I, 7F4H

ZINC - Investigational

MSHR_HUMAN

HPA

ENSG00000258839-MC1R

GeneCards

Q01726

Ensembl

ENST00000555147, ENST00000639847, ENSG00000258839, ENSP00000451605, ENSP00000492011

Pharos - Targets

Q01726

Orphanet

16925

ZINC - Predictions - Purchasable

MSHR_HUMAN

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