Melanocortin receptors bind melanocortins

Stable Identifier
R-HSA-388596
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Melanocortins are a group of pituitary peptide hormones that include corticotropin (ACTH) and the alpha, beta and gamma melanocyte-stimulating hormones (MSH) derived from the prohormone proopiomelanocortin (Takahashi H et al, 1981). Melanocortins can act through multiple melanocortin receptors (MC1R-MC5R) (Mountjoy KG et al, 1992). The majority of melanocortin receptors (MC1R, MC3R, MC4R and MC5R) are semi-selective in their ability to bind multiple melanocortins (MSH and ACTH). MSH regulates pigmentation.

Literature References
PubMed ID Title Journal Year
6274691 Isolation and structural organization of the human corticotropin--beta-lipotropin precursor gene

Takahashi, H, Teranishi, Y, Nakanishi, S, Numa, S

FEBS Lett 1981
1325670 The cloning of a family of genes that encode the melanocortin receptors

Mountjoy, KG, Robbins, LS, Mortrud, MT, Cone, RD

Science 1992
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