Reactome | Melanocortin receptors bind melanocortins

Melanocortin receptors bind melanocortins

Stable Identifier

R-HSA-388596

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Melanocortin receptors bind melanocortins

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Melanocortins are a group of pituitary peptide hormones that include corticotropin (ACTH) and the alpha, beta and gamma melanocyte-stimulating hormones (MSH) derived from the prohormone proopiomelanocortin (Takahashi H et al, 1981). Melanocortins can act through multiple melanocortin receptors (MC1R-MC5R) (Mountjoy KG et al, 1992). The majority of melanocortin receptors (MC1R, MC3R, MC4R and MC5R) are semi-selective in their ability to bind multiple melanocortins (MSH and ACTH). MSH regulates pigmentation.

Literature References

PubMed ID	Title	Journal	Year
1325670	The cloning of a family of genes that encode the melanocortin receptors Robbins, LS, Cone, RD, Mortrud, MT, Mountjoy, KG	Science	1992
6274691	Isolation and structural organization of the human corticotropin--beta-lipotropin precursor gene Numa, S, Nakanishi, S, Takahashi, H, Teranishi, Y	FEBS Lett	1981