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MC3R(1-360) [plasma membrane]
Stable Identifier
R-HSA-388592
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
MC3R, RecName: Full=Melanocortin receptor 3; AltName: Full=MC3-R;
GN Name=MC3R;
OS Homo sapiens, MC3R_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Melanocortin receptors bind melanocortins (Homo sapiens)
MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
Melanocortin receptors [plasma membrane] (Homo sapiens)
MC3R(1-360) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41968 MC3R
Gene Names
MC3R
Chain
chain:1-323
Reference Genes
BioGPS Gene:4159 MC3R
COSMIC (genes):MC3R MC3R
CTD Gene:4159 MC3R
dbSNP Gene:4159 MC3R
ENSEMBL:ENSG00000124089 MC3R
HGNC:6931 MC3R
KEGG Gene (Homo sapiens):4159 MC3R
Monarch:4159 MC3R
NCBI Gene:4159 MC3R
OMIM:155540 MC3R
UCSC:P41968 MC3R
Reference Transcript
RefSeq:NM_019888.3 MC3R
Other Identifiers
0004730500
11730680_at
16915006
221442_PM_at
221442_at
3890102
3890103
3890104
3890105
3890106
3890107
4159
8063476
A_14_P200576
A_23_P258525
GE57566
GO:0002027
GO:0003013
GO:0003674
GO:0004930
GO:0004977
GO:0004980
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0005887
GO:0007165
GO:0007186
GO:0007187
GO:0007188
GO:0007189
GO:0007200
GO:0008150
GO:0008217
GO:0016020
GO:0016021
GO:0017046
GO:0019222
GO:0032922
GO:0042309
GO:0042592
GO:0042923
GO:0045475
GO:0048511
GO:0055078
GO:0060259
HMNXSV003034675
ILMN_1667754
ILMN_1684933
PH_hs_0013135
TC20000426.hg
g9845270_3p_at
Participates
as a member of
Melanocortin receptors [plasma membrane] (Homo sapiens)
Inferred To
Mc3r [plasma membrane]
(Mus musculus)
Mc3r [plasma membrane]
(Rattus norvegicus)
MC3R [plasma membrane]
(Bos taurus)
MC3R [plasma membrane]
(Canis familiaris)
MC3R [plasma membrane]
(Gallus gallus)
MC3R [plasma membrane]
(Sus scrofa)
mc3r [plasma membrane]
(Danio rerio)
mc3r [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_063941.3
Guide to Pharmacology - Targets
284
OpenTargets
ENSG00000124089
ZINC - FDA approved
MC3R_HUMAN
ZINC - Substances
MC3R_HUMAN
ZINC target
P41968
PRO
P41968
ZINC - Investigational
MC3R_HUMAN
GeneCards
P41968
HPA
ENSG00000124089-MC3R
Ensembl
ENST00000243911
,
ENSG00000124089
,
ENSP00000243911
Pharos - Targets
P41968
Orphanet
18921
ZINC - Predictions - Purchasable
MC3R_HUMAN
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