Reactome | MC3R(1-323) [plasma membrane]

MC3R(1-323) [plasma membrane]

Stable Identifier

R-HSA-388592

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

MC3R, RecName: Full=Melanocortin receptor 3; AltName: Full=MC3-R;
GN Name=MC3R;
OS Homo sapiens, MC3R_HUMAN

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
    - p-S133-CREB1 binds MITF promoter (Homo sapiens)
      - MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)
        
        GPCRs that activate Gs [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Melanocortin receptors bind melanocortins (Homo sapiens)
        
        MSH:Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)
        
        Melanocortin receptors [plasma membrane] (Homo sapiens)
        
        MC3R(1-323) [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P41968 MC3R

Gene Names

MC3R

Chain

chain:1-323

Reference Genes

BioGPS Gene:4159 MC3R

COSMIC (genes):MC3R MC3R

CTD Gene:4159 MC3R

dbSNP Gene:4159 MC3R

ENSEMBL:ENSG00000124089 MC3R

HGNC:6931 MC3R

KEGG:hsa:4159 MC3R

Monarch:4159 MC3R

NCBI Gene:4159 MC3R

OMIM:155540 MC3R

UCSC:P41968 MC3R

Reference Transcript

RefSeq:NM_019888.3 MC3R

Other Identifiers

11730680_at

16915006

221442_PM_at

221442_at

3890102

3890103

3890104

3890105

3890106

3890107

4159

8063476

A_14_P200576

A_23_P258525

GE57566

GO:0002027

GO:0004930

GO:0004977

GO:0004980

GO:0005515

GO:0005737

GO:0005886

GO:0007186

GO:0007187

GO:0007188

GO:0007189

GO:0007200

GO:0008217

GO:0016020

GO:0017046

GO:0019222

GO:0032922

GO:0042309

GO:0042923

GO:0045475

GO:0048511

GO:0055078

GO:0060089

GO:0060259

HMNXSV003034675

ILMN_1667754

PH_hs_0013135

TC20000426.hg

g9845270_3p_at

Participates

as a member of

Melanocortin receptors [plasma membrane] (Homo sapiens)

Inferred To

Mc3r [plasma membrane] (Mus musculus)

Mc3r [plasma membrane] (Rattus norvegicus)

MC3R(1-323) [plasma membrane] (Gallus gallus)

MC3R [plasma membrane] (Bos taurus)

MC3R [plasma membrane] (Canis familiaris)

MC3R [plasma membrane] (Sus scrofa)

mc3r [plasma membrane] (Danio rerio)

mc3r [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_063941.3

Guide to Pharmacology - Targets

284

ENSEMBL

ENSP00000243911, ENST00000243911

OpenTargets

ENSG00000124089

ZINC - Substances

MC3R_HUMAN

ZINC target

P41968

PRO

P41968

GlyGen

P41968

PDB

8IOC

ZINC - Investigational

MC3R_HUMAN

HPA

ENSG00000124089-MC3R

Pharos - Targets

P41968

Orphanet

MC3R

ZINC - Predictions - Purchasable

MC3R_HUMAN