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EDNRB [plasma membrane]
Stable Identifier
R-HSA-388550
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Endothelin receptor B, RecName: Full=Endothelin B receptor; Short=ET-B; AltName: Full=Endothelin receptor non-selective type; Flags: Precursor; GN Name=EDNRB; Synonyms=ETRB; OS Homo sapiens, EDNRB_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MITF gene expression (Homo sapiens)
EDN1, EDN3:EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development (Homo sapiens)
EDN1, EDN3:EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
EDNRA, EDNRB bind non-selective ERAs (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
EDNRA,EDNRB bind EDNs (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
EDNRB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24530 EDNRB
Gene Names
EDNRB, ETRB
Chain
signal peptide:1-26, chain:27-442
Reference Genes
BioGPS Gene:1910 EDNRB
COSMIC (genes):EDNRB EDNRB
CTD Gene:1910 EDNRB
dbSNP Gene:1910 EDNRB
ENSEMBL:ENSG00000136160 EDNRB
HGNC:3180 EDNRB
KEGG:hsa:1910 EDNRB
Monarch:1910 EDNRB
NCBI Gene:1910 EDNRB
OMIM:131244 EDNRB
UCSC:P24530 EDNRB
Reference Transcript
RefSeq:NM_000115.4 EDNRB
RefSeq:NM_001201397.1 EDNRB
RefSeq:NM_003991.3 EDNRB
RefSeq:NM_001122659.2 EDNRB
Other Identifiers
11725664_a_at
11732906_a_at
11747223_a_at
11758445_s_at
1198_at
16779958
1910
204271_PM_s_at
204271_s_at
204273_PM_at
204273_at
206701_PM_x_at
206701_x_at
3518768
3518769
3518770
3518771
3518772
3518773
3518774
3518776
3518777
3518778
3518779
3518780
3518782
3518783
3518784
3518795
3518796
3518797
3518798
3518799
3518800
3518801
3518802
3518814
3518815
7972157
A_23_P2831
A_24_P330263
D13168_at
GE61126
GO:0000122
GO:0001755
GO:0002001
GO:0002027
GO:0002376
GO:0003012
GO:0003013
GO:0003014
GO:0004930
GO:0004962
GO:0005515
GO:0005886
GO:0006355
GO:0006629
GO:0006790
GO:0006885
GO:0007166
GO:0007186
GO:0007194
GO:0007200
GO:0007204
GO:0007399
GO:0007422
GO:0007497
GO:0008015
GO:0008217
GO:0008284
GO:0010467
GO:0014043
GO:0014070
GO:0014826
GO:0016020
GO:0017046
GO:0019722
GO:0019934
GO:0030154
GO:0030202
GO:0030318
GO:0031620
GO:0031702
GO:0031965
GO:0032341
GO:0032496
GO:0035645
GO:0035810
GO:0035812
GO:0042045
GO:0042310
GO:0042311
GO:0043066
GO:0043123
GO:0043473
GO:0048066
GO:0048246
GO:0048265
GO:0048484
GO:0048856
GO:0048870
GO:0050678
GO:0051248
GO:0055078
GO:0055085
GO:0060070
GO:0060089
GO:0060406
GO:0061028
GO:0065008
GO:0070294
GO:0070588
GO:0071222
GO:0071806
GO:0072112
GO:0086100
GO:0097018
GO:0097402
GO:0160093
GO:1901135
GO:1904383
GO:1990839
HMNXSV003006718
HMNXSV003036372
HMNXSV003039679
ILMN_1675100
ILMN_1751904
ILMN_2264916
PH_hs_0027713
TC13000748.hg
TC13001585.hg
g4503466_3p_a_at
g4557546_3p_at
p30268
Participates
as a component of
EDN1, EDN3:EDNRB [plasma membrane] (Homo sapiens)
as a member of
EDNRA,EDNRB [plasma membrane] (Homo sapiens)
Inferred To
EDNRB [plasma membrane]
(Bos taurus)
EDNRB [plasma membrane]
(Canis familiaris)
EDNRB [plasma membrane]
(Gallus gallus)
EDNRB [plasma membrane]
(Sus scrofa)
ednrb [plasma membrane]
(Xenopus tropicalis)
Ednrb [plasma membrane]
(Mus musculus)
Ednrb [plasma membrane]
(Rattus norvegicus)
ednrba [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001188326.1
,
NP_001116131.1
,
NP_000106.1
,
NP_003982.1
ZINC - World Drugs
EDNRB_HUMAN
Guide to Pharmacology - Targets
220
OpenTargets
ENSG00000136160
ENSEMBL
ENSP00000493527
,
ENST00000646605
,
ENST00000646948
,
ENSP00000493895
,
ENST00000377211
,
ENSP00000486202
,
ENST00000646607
,
ENST00000475537
,
ENST00000626030
,
ENSP00000366416
,
ENSP00000494278
,
ENSP00000487082
ZINC - FDA approved
EDNRB_HUMAN
ZINC - Substances
EDNRB_HUMAN
ZINC target
P24530
PRO
P24530
GlyGen
P24530
PDB
5XPR
,
8XGR
,
5X93
,
6IGL
,
8HBD
,
5GLH
,
5GLI
,
8IY5
,
6LRY
,
6IGK
,
8HCX
,
8IY6
ZINC - Investigational
EDNRB_HUMAN
HPA
ENSG00000136160-EDNRB
Pharos - Targets
P24530
Orphanet
EDNRB
ZINC - Predictions - Purchasable
EDNRB_HUMAN
HMDB Protein
HMDBP02537
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