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EDN2 [extracellular region]
Stable Identifier
R-HSA-388542
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
ET2, RecName: Full=Endothelin-2; Short=ET-2; AltName: Full=Preproendothelin-2; Short=PPET2; Flags: Precursor; GN Name=EDN2; OS Homo sapiens, EDN2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
EDNRA binds EDNs (Homo sapiens)
EDNRA:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
EDNRA,EDNRB bind EDNs (Homo sapiens)
EDNRA,EDNRB:EDNs [plasma membrane] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
EDNs [extracellular region] (Homo sapiens)
EDN2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20800 EDN2
Gene Names
EDN2
Chain
signal peptide:1-24, propeptide:25-46, peptide:49-69, propeptide:70-178
Reference Genes
BioGPS Gene:1907 EDN2
COSMIC (genes):EDN2 EDN2
CTD Gene:1907 EDN2
dbSNP Gene:1907 EDN2
ENSEMBL:ENSG00000127129 EDN2
HGNC:3177 EDN2
KEGG:hsa:1907 EDN2
Monarch:1907 EDN2
NCBI Gene:1907 EDN2
OMIM:131241 EDN2
UCSC:P20800 EDN2
Reference Transcript
RefSeq:NM_001956.4 EDN2
RefSeq:NM_001302269.1 EDN2
Other Identifiers
1092_at
11731286_at
16685923
1907
206758_PM_at
206758_at
2408666
2408667
2408668
2408669
2408670
2408671
2408672
2408673
2408674
2408675
2408676
2408677
2408678
7915385
A_23_P312150
GE79815
GO:0001516
GO:0001525
GO:0001659
GO:0001944
GO:0002376
GO:0002690
GO:0003012
GO:0003013
GO:0003058
GO:0003099
GO:0003100
GO:0005179
GO:0005576
GO:0005615
GO:0006629
GO:0006874
GO:0006939
GO:0007166
GO:0008284
GO:0009932
GO:0010460
GO:0014824
GO:0014826
GO:0019221
GO:0019229
GO:0030593
GO:0031175
GO:0031708
GO:0042116
GO:0042310
GO:0043542
GO:0045987
GO:0048018
GO:0048246
GO:0048286
GO:0048675
GO:0048856
GO:0048870
GO:0050850
GO:0050886
GO:0060585
GO:0097009
GO:0098772
HMNXSV003021548
ILMN_1680814
M65199_at
PH_hs_0000186
TC01002567.hg
TC01005426.hg
g4503462_3p_at
g4503462_3p_x_at
Participates
as a member of
EDNs [extracellular region] (Homo sapiens)
Inferred To
Edn2 [extracellular region]
(Mus musculus)
Edn2 [extracellular region]
(Rattus norvegicus)
edn2 [extracellular region]
(Xenopus tropicalis)
EDN2 [extracellular region]
(Bos taurus)
EDN2 [extracellular region]
(Canis familiaris)
EDN2 [extracellular region]
(Gallus gallus)
EDN2 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001947.1
,
NP_001289198.1
ENSEMBL
ENST00000372587
,
ENSG00000127129
,
ENSP00000361668
OpenTargets
ENSG00000127129
GeneCards
EDN2
HPA
ENSG00000127129-EDN2
PRO
P20800
Pharos - Targets
P20800
GlyGen
P20800
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