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CCKAR [plasma membrane]
Stable Identifier
R-HSA-388517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Cholecystokinin type A receptor, RecName: Full=Cholecystokinin receptor type A; AltName: Full=CCK-A receptor; Short=CCK-AR; AltName: Full=Cholecystokinin-1 receptor; Short=CCK1-R;
GN Name=CCKAR; Synonyms=CCKRA;
OS Homo sapiens, CCKAR_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKAR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKAR [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKAR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKAR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKAR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKAR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Cholecystokinin receptors bind cholecystokinin (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKAR [plasma membrane] (Homo sapiens)
CCKAR,CCKBR:CCK [plasma membrane] (Homo sapiens)
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
CCKAR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32238 CCKAR
Gene Names
CCKAR, CCKRA
Chain
chain:1-428
Reference Genes
BioGPS Gene:886 CCKAR
COSMIC (genes):CCKAR CCKAR
CTD Gene:886 CCKAR
dbSNP Gene:886 CCKAR
ENSEMBL:ENSG00000163394 CCKAR
HGNC:1570 CCKAR
KEGG:hsa:886 CCKAR
Monarch:886 CCKAR
NCBI Gene:886 CCKAR
OMIM:118444 CCKAR
UCSC:P32238 CCKAR
Reference Transcript
RefSeq:NM_000730.2 CCKAR
Other Identifiers
11715283_at
16975015
211174_PM_s_at
211174_s_at
2764491
2764492
2764493
2764494
2764495
2764497
2764498
2764499
2764500
32998_at
8099746
886
GE549795
GO:0001764
GO:0004930
GO:0004951
GO:0005654
GO:0005829
GO:0005886
GO:0007186
GO:0007200
GO:0007409
GO:0016020
GO:0017046
GO:0030900
GO:0032870
GO:0038188
GO:0042277
GO:0046883
GO:0048856
GO:0048870
GO:0060089
HMNXSV003016024
ILMN_1656330
PH_hs_0000021
TC04001095.hg
U23430_s_at
g306490_3p_a_at
Participates
as a member of
CCKAR,CCKBR [plasma membrane] (Homo sapiens)
Inferred To
Cckar [plasma membrane]
(Mus musculus)
Cckar [plasma membrane]
(Rattus norvegicus)
CCK1R [plasma membrane]
(Gallus gallus)
CCKAR [plasma membrane]
(Bos taurus)
CCKAR [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000721.1
Guide to Pharmacology - Targets
76
ENSEMBL
ENSG00000163394
,
ENST00000295589
,
ENSP00000295589
OpenTargets
ENSG00000163394
ZINC - FDA approved
CCKAR_HUMAN
ZINC - Substances
CCKAR_HUMAN
ZINC - Biogenic
CCKAR_HUMAN
ZINC target
P32238
PRO
P32238
GlyGen
P32238
PDB
1HZN
,
7F8X
,
7F8Y
,
7F8U
,
7XOU
,
7EZM
,
7EZK
,
7EZH
,
1D6G
,
7XOV
,
9BKK
,
7MBY
,
9BKJ
,
7MBX
ZINC - Investigational
CCKAR_HUMAN
GeneCards
CCKAR
HPA
ENSG00000163394-CCKAR
Pharos - Targets
P32238
ZINC - Predictions - Purchasable
CCKAR_HUMAN
HMDB Protein
HMDBP07570
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