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AVPR1B [plasma membrane]
Stable Identifier
R-HSA-388471
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
RecName: Full=Vasopressin V1b receptor; AltName: Full=AVPR V1b; AltName: Full=V1bR; AltName: Full=Vasopressin V3 receptor; AltName: Full=AVPR V3; AltName: Full=Antidiuretic hormone receptor 1b;
GN Name=AVPR1B; Synonyms=AVPR3, VPR3;
OS Homo sapiens, V1BR_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) (Homo sapiens)
Defective AVP mutants do not bind AVPR1A,B (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Vasopressin-like receptors (Homo sapiens)
AVP(20-28) binds AVPR1A,B (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
AVPR1A,B:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
AVPR1A,B bind desmopressin (Homo sapiens)
AVPR1A,1B:desmopressin [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
AVPR1A,B,2 bind atosiban (Homo sapiens)
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
AVPR1A,B,2:atosiban [plasma membrane] (Homo sapiens)
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
AVPR1B [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P47901 AVPR1B
Gene Names
AVPR1B, AVPR3, VPR3
Chain
chain:1-424
Reference Genes
BioGPS Gene:553 AVPR1B
COSMIC (genes):AVPR1B AVPR1B
CTD Gene:553 AVPR1B
dbSNP Gene:553 AVPR1B
ENSEMBL:ENSG00000198049 AVPR1B
HGNC:896 AVPR1B
KEGG:hsa:553 AVPR1B
Monarch:553 AVPR1B
NCBI Gene:553 AVPR1B
OMIM:600264 AVPR1B
UCSC:P47901 AVPR1B
Reference Transcript
RefSeq:NM_000707.3 AVPR1B
Other Identifiers
11738078_at
16676542
208260_PM_at
208260_at
4066359
4073013
4077044
4135187
4135691
553
627_g_at
648_at
7909155
A_23_P72340
D31833_s_at
GE80577
GO:0001992
GO:0003013
GO:0004930
GO:0005000
GO:0005080
GO:0005768
GO:0005794
GO:0005886
GO:0007186
GO:0007200
GO:0007204
GO:0008217
GO:0016020
GO:0031410
GO:0032430
GO:0032870
GO:0042127
GO:0042277
GO:0043226
GO:0043410
GO:0045907
GO:0046718
GO:0050886
GO:0060089
GO:0060732
GO:0090238
GO:0150104
HMNXSV003015700
ILMN_1680521
L37112_at
PH_hs_0027530
TC01001719.hg
g13112055_3p_at
Participates
as a member of
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
AVPR1A,B [plasma membrane] (Homo sapiens)
Inferred To
AVPR1B [plasma membrane]
(Bos taurus)
AVPR1B [plasma membrane]
(Canis familiaris)
AVPR1B [plasma membrane]
(Gallus gallus)
AVPR1B [plasma membrane]
(Sus scrofa)
avpr1ab [plasma membrane]
(Danio rerio)
avpr1b [plasma membrane]
(Xenopus tropicalis)
Avpr1b [plasma membrane]
(Mus musculus)
avpr1aa [plasma membrane]
(Danio rerio)
Homologues of AVPR1B [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_000698.1
Guide to Pharmacology - Targets
367
ENSEMBL
ENSG00000198049
,
ENSP00000356094
,
ENST00000367126
OpenTargets
ENSG00000198049
ZINC - Substances
V1BR_HUMAN
ZINC target
P47901
PRO
P47901
GlyGen
P47901
ZINC - Investigational
V1BR_HUMAN
GeneCards
AVPR1B
HPA
ENSG00000198049-AVPR1B
Pharos - Targets
P47901
ZINC - Predictions - Purchasable
V1BR_HUMAN
HMDB Protein
HMDBP01826
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