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AVPR2 [plasma membrane]
Stable Identifier
R-HSA-388431
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Vasopressin receptor type 2, RecName: Full=Vasopressin V2 receptor; AltName: Full=AVPR V2; AltName: Full=Renal-type arginine vasopressin receptor; AltName: Full=Antidiuretic hormone receptor;
GN Name=AVPR2; Synonyms=ADHR, DIR, DIR3, V2R;
OS Homo sapiens, V2R_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Disorders of transmembrane transporters (Homo sapiens)
SLC transporter disorders (Homo sapiens)
Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) (Homo sapiens)
Defective AVP mutants do not bind AVPR2 (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Vasopressin-like receptors (Homo sapiens)
AVP(20-28) binds AVPR2 (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR1A,2 bind AVPR antagonists (Homo sapiens)
AVPR1A,2 [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR1A,2:AVPR antagonists [plasma membrane] (Homo sapiens)
AVPR1A,2 [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR1A,B,2 bind atosiban (Homo sapiens)
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR1A,B,2:atosiban [plasma membrane] (Homo sapiens)
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR2 bind desmopressin (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR2:desmopressin [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Aquaporin-mediated transport (Homo sapiens)
Vasopressin regulates renal water homeostasis via Aquaporins (Homo sapiens)
AVP(20-28) binds AVPR2 (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVP:AVPR2 Complex binds inactive heterotrimeric G(s) complex (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVP:AVPR2:heterotrimeric G(s) complex exchanges GDP for GTP (Homo sapiens)
AVPR2:AVP:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
AVPR2:AVP:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
ADBRK1,2 phosphorylate AVPR2 (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
AVPR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30518 AVPR2
Gene Names
AVPR2, ADHR, DIR, DIR3, V2R
Chain
chain:1-371
Reference Genes
BioGPS Gene:554 AVPR2
COSMIC (genes):AVPR2 AVPR2
CTD Gene:554 AVPR2
dbSNP Gene:554 AVPR2
ENSEMBL:ENSG00000126895 AVPR2
HGNC:897 AVPR2
KEGG:hsa:554 AVPR2
Monarch:554 AVPR2
NCBI Gene:554 AVPR2
OMIM:300538 AVPR2
UCSC:P30518 AVPR2
Reference Transcript
RefSeq:NM_001146151.1 AVPR2
RefSeq:NM_000054.4 AVPR2
RefSeq:XM_006724828.3 AVPR2
Other Identifiers
11745688_a_at
17108213
208108_PM_s_at
208108_s_at
208111_PM_at
208111_at
3996046
3996048
3996049
3996050
3996051
3996052
3996053
3996054
3996055
3996056
3996062
3996064
554
667_at
8170794
A_14_P131078
A_23_P346800
GE57677
GO:0001992
GO:0003013
GO:0003014
GO:0003084
GO:0003092
GO:0004930
GO:0005000
GO:0005515
GO:0005768
GO:0005783
GO:0005794
GO:0005886
GO:0007186
GO:0007188
GO:0007190
GO:0007599
GO:0008284
GO:0008285
GO:0010628
GO:0016020
GO:0021537
GO:0030139
GO:0030669
GO:0031410
GO:0032870
GO:0034097
GO:0035811
GO:0038023
GO:0042277
GO:0043226
GO:0045777
GO:0045907
GO:0048471
GO:0048856
GO:0050886
GO:0060089
GO:1902533
HMNXSV003042581
ILMN_1698324
L22206_at
PH_hs_0000336
TC0X000760.hg
TC0X001930.hg
g2623239_3p_a_at
Participates
as an input of
Defective AVP mutants do not bind AVPR2 (Homo sapiens)
AVPR2 bind desmopressin (Homo sapiens)
AVP(20-28) binds AVPR2 (Homo sapiens)
as a component of
AVPR2:desmopressin [plasma membrane] (Homo sapiens)
AVPR2:AVP(20-28) [plasma membrane] (Homo sapiens)
as a member of
AVPR1A,2 [plasma membrane] (Homo sapiens)
AVPR1A,B, 2 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-AVPR2 [plasma membrane]
AVPR2 [clathrin-coated endocytic vesicle membrane]
Inferred To
avpr2 [plasma membrane]
(Xenopus tropicalis)
avpr2l [plasma membrane]
(Danio rerio)
AVPR2 [plasma membrane]
(Bos taurus)
AVPR2 [plasma membrane]
(Canis familiaris)
AVPR2 [plasma membrane]
(Sus scrofa)
Avpr2 [plasma membrane]
(Mus musculus)
Avpr2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_006724891.1
,
NP_001139623.1
,
NP_000045.1
ZINC - World Drugs
V2R_HUMAN
Guide to Pharmacology - Targets
368
OpenTargets
ENSG00000126895
ENSEMBL
ENST00000646375
,
ENSP00000496396
,
ENST00000337474
,
ENST00000370049
,
ENSP00000359066
,
ENSP00000338072
ZINC - FDA approved
V2R_HUMAN
ZINC - Substances
V2R_HUMAN
ZINC - Biogenic
V2R_HUMAN
ZINC target
P30518
PRO
P30518
GlyGen
P30518
PDB
4JQI
,
8JRU
,
6U1N
,
7KH0
,
7R0C
,
8WRZ
,
8WU1
,
8JRV
,
7R0J
,
7DW9
,
7BB6
,
6NI2
,
8I10
,
7BB7
,
7DFA
,
7DF9
,
7DFC
,
8GOC
,
7DFB
ZINC - Investigational
V2R_HUMAN
ZINC - Metabolites
V2R_HUMAN
HPA
ENSG00000126895-AVPR2
Pharos - Targets
P30518
Orphanet
AVPR2
ZINC - Predictions - Purchasable
V2R_HUMAN
HMDB Protein
HMDBP01725
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21964 COMT
2
COMT [cytosol]
(R-HSA-175974)
COMT [plasma membrane]
(R-HSA-379386)
0.556
3
IntAct:EBI-23343277 CCSB ORF ID
0.556
3
UniProt:Q8IVJ1 SLC41A1
1
SLC41A1 [plasma membrane]
(R-HSA-442659)
0.556
3
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