WNTs bind the FZD receptor to initiate PCP pathway

Stable Identifier
R-HSA-3858491
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Detailed biochemical analyses of all the WNT ligand-receptor interactions that initiate the planar cell polarity pathway are not fully elucidated (reviewed in Gao et al, 2012). In Xenopus embryos, direct interaction between Wnt11 and Fzd7 has been shown to be required for convergent extension during gastrulation (Djiane et al, 2000), In mouse Fzd 1, 2, 3 and 6 have known roles in neural tube closure and cochlear hair orientation, two typical PCP processes, although the initiating ligands have not been clearly defined (Guo et al, 2004; Wang et al, 2006; Yu et al, 2010). Similarly, vertebrate Wnt5a and Wnt11 are implicated in numerous PCP processes including limb bud formation, neural tube closure, hair orientation and cytoskeletal rearrangements, but a direct interaction with a FZD receptor has not been demonstrated in all cases (Gao et al, 2011; Qian et al, 2007).

Literature References
PubMed ID Title Journal Year
21316585 Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

Gao, B, Song, H, Bishop, K, Elliot, G, Garrett, L, English, MA, Andre, P, Robinson, J, Sood, R, Minami, Y, Economides, AN, Yang, Y

Dev. Cell 2011
10862746 Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis

Djiane, A, Riou, J, Umbhauer, M, Boucaut, JC, Shi, D

Development 2000
17433286 Wnt5a functions in planar cell polarity regulation in mice

Qian, D, Jones, C, Rzadzinska, A, Mark, S, Zhang, X, Steel, KP, Dai, X, Chen, P

Dev. Biol. 2007
20940229 Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes

Yu, H, Smallwood, PM, Wang, Y, Vidaltamayo, R, Reed, R, Nathans, J

Development 2010
16495441 The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells

Wang, Y, Guo, N, Nathans, J

J. Neurosci. 2006
15169958 Frizzled6 controls hair patterning in mice

Guo, N, Hawkins, C, Nathans, J

Proc. Natl. Acad. Sci. U.S.A. 2004
23140633 Wnt regulation of planar cell polarity (PCP)

Gao, B

Curr. Top. Dev. Biol. 2012
Participants
Participant Of
hasEvent
Inferred From
Authored
Reviewed
Created