Reactome | CEBPB homodimerization

CEBPB homodimerization

Stable Identifier

R-HSA-3857336

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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RSK1/2/3-mediated phosphorylation of CEBPB promotes the formation of CEBPB homodimers which are active as transcription factors (Lee, Miller et al. 2010; Lee, Shuman et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20351173	RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity Shuman, JD, Cohen, MS, Sakchaisri, K, Taunton, J, Lee, S, Sebastian, T, Smart, RC, Veenstra, TD, Xiao, Z, Yu, LR, Miller, M, Copeland, TD, Guszczynski, T, Johnson, PF	Mol. Cell. Biol.	2010
20452968	CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP) Shuman, JD, Miller, M, Johnson, PF, Lee, S	J. Biol. Chem.	2010