Activated CEBPB and NFKB complex bind IL6 promoter

Stable Identifier
R-HSA-3857305
Type
Reaction
Species
Homo sapiens
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Summation

RSK6A1/2/3-mediated phosphorylation of CEBPB downstream of activated RAS stimulates CEBPB homodimerization and DNA binding (Lee, Shuman et al. 2010) and, specifically, RAS-induced CEBPB activation stimulates CEBPB binding to the IL6 promoter (Kuilman et al. 2008; Lee, Shuman et al. 2010). RAS-activated CEBPB is able to recruit additional transcription activators, such as EP300, to the IL6 promoter (Lee, Miller et al. 2010). NFKB transcription complex, activated by interleukin-1-alpha (IL1A) signaling (Jimi et al. 1996, Hartupee et al. 2008, Orjalo et al. 2009), also binds the promoter of the IL6 gene (Shimizu et al. 1990, Libermann and Baltimore 1990) and cooperates with CEBPB in the activation of IL6 transcription (Matsusaka et al. 1993).

Literature References
PubMed ID Title Journal Year
8617720 Interleukin-1 alpha activates an NF-kappaB-like factor in osteoclast-like cells

Jimi, E, Ikebe, T, Takahashi, N, Hirata, M, Suda, T, Koga, T

J. Biol. Chem. 1996
20351173 RSK-mediated phosphorylation in the C/EBP{beta} leucine zipper regulates DNA binding, dimerization, and growth arrest activity

Lee, S, Shuman, JD, Guszczynski, T, Sakchaisri, K, Sebastian, T, Copeland, TD, Miller, M, Cohen, MS, Taunton, J, Smart, RC, Xiao, Z, Yu, LR, Veenstra, TD, Johnson, PF

Mol. Cell. Biol. 2010
18411265 Interleukin 1alpha-induced NFkappaB activation and chemokine mRNA stabilization diverge at IRAK1

Hartupee, J, Li, X, Hamilton, T

J. Biol. Chem. 2008
2405250 Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines

Shimizu, H, Mitomo, K, Watanabe, T, Okamoto, S, Yamamoto, K

Mol. Cell. Biol. 1990
19805069 Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

Orjalo, AV, Bhaumik, D, Gengler, BK, Scott, GK, Campisi, J

Proc. Natl. Acad. Sci. U.S.A. 2009
8234276 Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8

Matsusaka, T, Fujikawa, K, Nishio, Y, Mukaida, N, Matsushima, K, Kishimoto, T, Akira, S

Proc. Natl. Acad. Sci. U.S.A. 1993
18555778 Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

Kuilman, T, Michaloglou, C, Vredeveld, LC, Douma, S, van Doorn, R, Desmet, CJ, Aarden, LA, Mooi, WJ, Peeper, DS

Cell 2008
2183031 Activation of interleukin-6 gene expression through the NF-kappa B transcription factor

Libermann, TA, Baltimore, D

Mol. Cell. Biol. 1990
20452968 CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP)

Lee, S, Miller, M, Shuman, JD, Johnson, PF

J. Biol. Chem. 2010
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