Release of novel PDGFs as latent factors

Stable Identifier
R-HSA-382057
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region, Golgi membrane
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Release of novel PDGFs as latent factors
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Novel PDGFs both PDGF-CC and PDGF-DD dimers are secreted as latent factors without removal of the N-terminal CUB domain. These require further activation by extracellular proteolysis.

Literature References
PubMed ID Title Journal Year
15207811 The PDGF family: four gene products form five dimeric isoforms

Fredriksson, L, Li, H, Eriksson, U

Cytokine Growth Factor Rev 2004
Participants
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Orthologous Events
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Release of novel PDGFs as latent factors (Danio rerio)
Release of novel PDGFs as latent factors (Drosophila melanogaster)
Release of novel PDGFs as latent factors (Gallus gallus)
Release of novel PDGFs as latent factors (Mus musculus)
Release of novel PDGFs as latent factors (Rattus norvegicus)
Release of novel PDGFs as latent factors (Sus scrofa)
Release of novel PDGFs as latent factors (Xenopus tropicalis)
Authored
Garapati, P V  (2008-11-24)
Jassal, B  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-24)
Created
Garapati, P V  (2008-11-22)