Release of novel PDGFs as latent factors

Stable Identifier
R-HSA-382057
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
extracellular region, Golgi membrane
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Release of novel PDGFs as latent factors
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Novel PDGFs both PDGF-CC and PDGF-DD dimers are secreted as latent factors without removal of the N-terminal CUB domain. These require further activation by extracellular proteolysis.

Literature References
PubMed ID Title Journal Year
15207811 The PDGF family: four gene products form five dimeric isoforms

Li, H, Eriksson, U, Fredriksson, L

Cytokine Growth Factor Rev 2004
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Authored
Jassal, B  (2008-11-24)
Garapati, P V  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-23)
Created
Garapati, P V  (2008-11-21)
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