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Translocation of PDGF from ER to Golgi
Stable Identifier
R-HSA-382053
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane
,
endoplasmic reticulum lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Translocation of PDGF from ER to Golgi (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
All the newly synthesized PDGF chains are dimerized in the ER and thereafter transferred to the Golgi complex for proteolytic processing. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD.
Literature References
PubMed ID
Title
Journal
Year
1639841
PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly
Westermark, B
,
Ostman, A
,
Heldin, CH
,
Thyberg, J
J Cell Biol
1992
15207811
The PDGF family: four gene products form five dimeric isoforms
Li, H
,
Eriksson, U
,
Fredriksson, L
Cytokine Growth Factor Rev
2004
Participants
Input
PDGF precursor dimers (AA, BB, A/B, CC, DD) [endoplasmic reticulum lumen]
(Homo sapiens)
Output
PDGF precursor dimers (AA, BB, A/B, CC, DD) [Golgi membrane]
(Homo sapiens)
Participates
as an event of
Signaling by PDGF (Homo sapiens)
Orthologous Events
Translocation of PDGF from ER to Golgi (Bos taurus)
Translocation of PDGF from ER to Golgi (Caenorhabditis elegans)
Translocation of PDGF from ER to Golgi (Canis familiaris)
Translocation of PDGF from ER to Golgi (Danio rerio)
Translocation of PDGF from ER to Golgi (Drosophila melanogaster)
Translocation of PDGF from ER to Golgi (Gallus gallus)
Translocation of PDGF from ER to Golgi (Mus musculus)
Translocation of PDGF from ER to Golgi (Rattus norvegicus)
Translocation of PDGF from ER to Golgi (Sus scrofa)
Translocation of PDGF from ER to Golgi (Xenopus tropicalis)
Authored
Jassal, B (2008-11-24)
Garapati, P V (2008-11-24)
Reviewed
Heldin, CH (2008-11-24)
Created
Garapati, P V (2008-11-22)
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