Translocation of PDGF from ER to Golgi

Stable Identifier
R-HSA-382053
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
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Translocation of PDGF from ER to Golgi
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All the newly synthesized PDGF chains are dimerized in the ER and thereafter transferred to the Golgi complex for proteolytic processing. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD.
Literature References
PubMed ID Title Journal Year
1639841 PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly

Westermark, B, Ostman, A, Heldin, CH, Thyberg, J

J Cell Biol 1992
15207811 The PDGF family: four gene products form five dimeric isoforms

Li, H, Eriksson, U, Fredriksson, L

Cytokine Growth Factor Rev 2004
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Orthologous Events
Translocation of PDGF from ER to Golgi (Bos taurus)
Translocation of PDGF from ER to Golgi (Caenorhabditis elegans)
Translocation of PDGF from ER to Golgi (Canis familiaris)
Translocation of PDGF from ER to Golgi (Danio rerio)
Translocation of PDGF from ER to Golgi (Drosophila melanogaster)
Translocation of PDGF from ER to Golgi (Gallus gallus)
Translocation of PDGF from ER to Golgi (Mus musculus)
Translocation of PDGF from ER to Golgi (Rattus norvegicus)
Translocation of PDGF from ER to Golgi (Sus scrofa)
Translocation of PDGF from ER to Golgi (Xenopus tropicalis)
Authored
Jassal, B  (2008-11-24)
Garapati, P V  (2008-11-24)
Reviewed
Heldin, CH  (2008-11-24)
Created
Garapati, P V  (2008-11-22)
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