Translocation of PDGF from ER to Golgi

Stable Identifier
R-HSA-382053
Type
Reaction
Species
Homo sapiens
Compartment
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All the newly synthesized PDGF chains are dimerized in the ER and thereafter transferred to the Golgi complex for proteolytic processing. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD.

Literature References
PubMed ID Title Journal Year
1639841 PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly

Westermark, B, Ostman, A, Heldin, CH, Thyberg, J

J Cell Biol 1992
15207811 The PDGF family: four gene products form five dimeric isoforms

Li, H, Eriksson, U, Fredriksson, L

Cytokine Growth Factor Rev 2004
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