Reactome | Translocation of PDGF from ER to Golgi

Translocation of PDGF from ER to Golgi

Stable Identifier

R-HSA-382053

Type

Reaction

Species

Homo sapiens

Compartment

Golgi membrane, endoplasmic reticulum lumen

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All the newly synthesized PDGF chains are dimerized in the ER and thereafter transferred to the Golgi complex for proteolytic processing. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD.

Literature References

PubMed ID	Title	Journal	Year
1639841	PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly Westermark, B, Ostman, A, Heldin, CH, Thyberg, J	J Cell Biol	1992
15207811	The PDGF family: four gene products form five dimeric isoforms Li, H, Eriksson, U, Fredriksson, L	Cytokine Growth Factor Rev	2004