Reactome | PDGFA-1(1-211) [endoplasmic reticulum lumen]

PDGFA-1(1-211) [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-381910

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Platelet-derived growth factor, A chain precursor, PDGF A-chain isofrorm 1

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PDGF (Homo sapiens)
    - Translocation of PDGF from ER to Golgi (Homo sapiens)
      - PDGF precursor dimers (AA, BB, A/B, CC, DD) [endoplasmic reticulum lumen] (Homo sapiens)
        
        PDGF A-chain precursor dimer [endoplasmic reticulum lumen] (Homo sapiens)
        
        PDGF A isoforms [endoplasmic reticulum lumen] (Homo sapiens)
        
        PDGFA-1(1-211) [endoplasmic reticulum lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04085-1 PDGFA

Gene Names

PDGFA, PDGF1

Other Identifiers

1109_s_at

11729062_a_at

11729063_a_at

11750974_a_at

17054243

205463_PM_s_at

205463_s_at

216867_PM_s_at

216867_s_at

35703_at

4049075

4049082

4049083

4049419

4049421

4049426

4049428

4049430

4049431

4049440

5154

8137670

A_33_P3372666

GE59683

GO:0000139

GO:0001525

GO:0001775

GO:0001942

GO:0002053

GO:0005161

GO:0005515

GO:0005518

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005902

GO:0006629

GO:0007010

GO:0007267

GO:0008083

GO:0008284

GO:0009611

GO:0009887

GO:0009986

GO:0010512

GO:0010544

GO:0014910

GO:0016020

GO:0023052

GO:0030031

GO:0030036

GO:0030335

GO:0031093

GO:0031410

GO:0031954

GO:0032956

GO:0035790

GO:0035793

GO:0036211

GO:0042060

GO:0042802

GO:0042803

GO:0043226

GO:0043406

GO:0043410

GO:0043588

GO:0046982

GO:0048008

GO:0048018

GO:0048146

GO:0048286

GO:0048407

GO:0048856

GO:0048870

GO:0050730

GO:0050919

GO:0051781

GO:0051897

GO:0060683

GO:0070374

GO:0098772

GO:1990265

GO:1990401

HMNXSV003003506

HMNXSV003023053

HMNXSV003029734

HMNXSV003038532

Hs.37040.2.S1_3p_a_at

ILMN_1685982

ILMN_1782661

ILMN_2342695

M19989_cds2_at

PH_hs_0028268

TC07001073.hg

g4505678_3p_at

Participates

as a member of

PDGF A isoforms [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

PDGFA-1 [platelet alpha granule lumen]

N-ter PDGFA-1 fragment [Golgi lumen]

PDGFA-1(1-211) [Golgi membrane]

PDGFA-1 [extracellular region]

Inferred To

PDGF-A (L) [endoplasmic reticulum lumen] (Gallus gallus)

PDGFA [endoplasmic reticulum lumen] (Bos taurus)

PDGFA [endoplasmic reticulum lumen] (Canis familiaris)

PDGFA [endoplasmic reticulum lumen] (Sus scrofa)

Pdgfa [endoplasmic reticulum lumen] (Mus musculus)

Pdgfa [endoplasmic reticulum lumen] (Rattus norvegicus)

pdgfab [endoplasmic reticulum lumen] (Danio rerio)

pvf-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Pvf1 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_002598.4, NP_148983.1

OpenTargets

ENSG00000197461

HPA

ENSG00000197461-PDGFA

GeneCards

P04085

ZINC - Substances

PDGFA_HUMAN

Ensembl

ENSP00000383889, ENST00000402802, ENST00000354513, ENSP00000346508, ENSG00000197461

ZINC target

P04085

PRO

P04085

Pharos - Targets

P04085

ZINC - Predictions - Purchasable

PDGFA_HUMAN

PDB

3MJK

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.691	6
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.524	5