By analogy with adenylyl cyclases I and II, adenylyl cyclase VIII is activated by G(s) alpha:GTP by protein-protein interaction between G(s) alpha and the C2 region of adenylyl cyclase VIII, forming a complex. Adenylyl cyclase VIII is present in beta cells of rat and is activated by both G(s) alpha:GTP and calcium:calmodulin, thus integrating signals from both GLP-1 via G(s) alpha and glucose via calcium. Human beta cells contain adenylyl cyclases V and VI, which are also activated by G(s) alpha:GTP, and may contain additional adenylyl cyclases.
Brock, B, Gromada, J, Rorsman, P, Schmitz, O
Schuit, F, Delmeire, D, Cali, JJ, Hinke, SA, Pipeleers, D, Flamez, D
Sunahara, RK, Tesmer, JJ, Gilman, AG, Sprang, SR
Habener, JF, Castonguay, MA, Leech, CA
Ahren, B, Winzell, MS
Egan, JM, Doyle, ME
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