G(s):GTP activates Adenylyl cyclase

Stable Identifier
R-HSA-381704
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
G(s):GTP activates Adenylyl cyclase
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

By analogy with adenylyl cyclases I and II, adenylyl cyclase VIII is activated by G(s) alpha:GTP by protein-protein interaction between G(s) alpha and the C2 region of adenylyl cyclase VIII, forming a complex. Adenylyl cyclase VIII is present in beta cells of rat and is activated by both G(s) alpha:GTP and calcium:calmodulin, thus integrating signals from both GLP-1 via G(s) alpha and glucose via calcium. Human beta cells contain adenylyl cyclases V and VI, which are also activated by G(s) alpha:GTP, and may contain additional adenylyl cyclases.

Literature References
PubMed ID Title Journal Year
13680124 Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1

Delmeire, D, Flamez, D, Hinke, SA, Cali, JJ, Pipeleers, D, Schuit, F

Diabetologia 2003
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Gromada, J, Brock, B, Schmitz, O, Rorsman, P

Basic Clin Pharmacol Toxicol 2004
9417641 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Tesmer, JJ, Sunahara, RK, Gilman, AG, Sprang, SR

Science 1997
9920805 Expression of adenylyl cyclase subtypes in pancreatic beta-cells

Leech, CA, Castonguay, MA, Habener, JF

Biochem Biophys Res Commun 1999
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Winzell, MS, Ahren, B

Pharmacol Ther 2007
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Doyle, ME, Egan, JM

Pharmacol Ther 2007
Participants
Input
Output
Participates
as an event of
Authored
May, B  (2009-05-28)
Reviewed
Gillespie, ME  (2009-06-02)
Created
May, B  (2008-11-20)
Cite Us!