G(s):GTP activates Adenylyl cyclase

Stable Identifier
Reaction [transition]
Homo sapiens
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By analogy with adenylyl cyclases I and II, adenylyl cyclase VIII is activated by G(s) alpha:GTP by protein-protein interaction between G(s) alpha and the C2 region of adenylyl cyclase VIII, forming a complex. Adenylyl cyclase VIII is present in beta cells of rat and is activated by both G(s) alpha:GTP and calcium:calmodulin, thus integrating signals from both GLP-1 via G(s) alpha and glucose via calcium. Human beta cells contain adenylyl cyclases V and VI, which are also activated by G(s) alpha:GTP, and may contain additional adenylyl cyclases.
Literature References
PubMed ID Title Journal Year
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Brock, B, Gromada, J, Rorsman, P, Schmitz, O

Basic Clin Pharmacol Toxicol 2004
13680124 Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1

Schuit, F, Delmeire, D, Cali, JJ, Hinke, SA, Pipeleers, D, Flamez, D

Diabetologia 2003
9417641 Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS

Sunahara, RK, Tesmer, JJ, Gilman, AG, Sprang, SR

Science 1997
9920805 Expression of adenylyl cyclase subtypes in pancreatic beta-cells

Habener, JF, Castonguay, MA, Leech, CA

Biochem Biophys Res Commun 1999
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Egan, JM, Doyle, ME

Pharmacol Ther 2007
Catalyst Activity

adenylate cyclase activator activity of G alpha (s):GTP [plasma membrane]

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