GLP1R binds GLP1

Stable Identifier
Reaction [transition]
Homo sapiens
Glucagon-like Peptide-1 Receptor (GLP1R) binds Glucagon-like peptide-1
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Glucagon-like Peptide-1 is synthesized in intestinal L-cells in response to the presence of glucose and fatty acids absorbed from the intestine. Most GLP-1 is the GLP-1 (7-36) amidated form; some GLP-1 is the GLP-1 (7-37) form. GLP-1 circulates to the pancreas where it binds the Glucagon-like Peptide-1 Receptor (GLP-1R), a G-protein coupled receptor located on the plasma membrane of beta cells. GLP-1R is a seven-pass transmembrane protein and a member of the B family of GPCRs, which have N-terminal extracellular domains of 100-150 amino acids. GLP-1 interacts with the extracellular N-terminal region of GLP-1R.
Literature References
PubMed ID Title Journal Year
8404634 Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor

Rabin, DU, Ligon, BB, Leng, XH, Wheeler, MB, Boyd AE, 3rd, Tanizawa, Y, Dillon, JS, Yoo-Warren, H, Permutt, MA

Endocrinology 1993
7589461 Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

Wulff, BS, Gromada, J, Dissing, S, Rorsman, P

FEBS Lett 1995
15569269 Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

Brock, B, Gromada, J, Rorsman, P, Schmitz, O

Basic Clin Pharmacol Toxicol 2004
12034449 In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor

Schaefer, W, Reusch, D, Rudolph, R, Panzner, S, Wozny, M, Grauschopf, U, Bazarsuren, A, Hoffmann, E

Biophys Chem 2002
18287102 Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

Lau, J, Rudolph, R, Madsen, K, Thøgersen, H, Runge, S

J Biol Chem 2008
19861722 Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor

Peters, GH, Knudsen, LB, Reedtz-Runge, S, Rudolph, R, Underwood, CR, Hastrup, S, Garibay, P

J Biol Chem 2009
8405712 Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor

Morel, P, Widmann, C, Thorens, B, Porret, A, Buhler, L, Deng, SP

Diabetes 1993
8138058 Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans

Orskov, C, Rabenhøj, L, Kofod, H, Wettergren, A, Holst, JJ

Diabetes 1994
17306374 Mechanisms of action of glucagon-like peptide 1 in the pancreas

Egan, JM, Doyle, ME

Pharmacol Ther 2007
17444618 Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain

Lau, J, Schimmer, S, Rudolph, R, Madsen, K, Schiødt, CB, Thøgersen, H, Jeppesen, CB, Runge, S, Knudsen, SM, Oschmann, J

Biochemistry 2007
Catalyst Activity

receptor ligand activity of mature GLP1 [extracellular region]

Orthologous Events
Cite Us!