Reactome | GLP1R binds GLP1

GLP1R binds GLP1

Stable Identifier

R-HSA-381612

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Glucagon-like Peptide-1 Receptor (GLP1R) binds Glucagon-like peptide-1

ReviewStatus

5/5

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Glucagon-like Peptide-1 is synthesized in intestinal L-cells in response to the presence of glucose and fatty acids absorbed from the intestine. Most GLP-1 is the GLP-1 (7-36) amidated form; some GLP-1 is the GLP-1 (7-37) form. GLP-1 circulates to the pancreas where it binds the Glucagon-like Peptide-1 Receptor (GLP-1R), a G-protein coupled receptor located on the plasma membrane of beta cells. GLP-1R is a seven-pass transmembrane protein and a member of the B family of GPCRs, which have N-terminal extracellular domains of 100-150 amino acids. GLP-1 interacts with the extracellular N-terminal region of GLP-1R.

Literature References

PubMed ID	Title	Journal	Year
8404634	Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor Rabin, DU, Ligon, BB, Leng, XH, Wheeler, MB, Boyd AE, 3rd, Tanizawa, Y, Dillon, JS, Yoo-Warren, H, Permutt, MA	Endocrinology	1993
7589461	Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release Wulff, BS, Gromada, J, Dissing, S, Rorsman, P	FEBS Lett	1995
15569269	Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential Brock, B, Gromada, J, Rorsman, P, Schmitz, O	Basic Clin Pharmacol Toxicol	2004
12034449	In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor Schaefer, W, Reusch, D, Rudolph, R, Panzner, S, Wozny, M, Grauschopf, U, Bazarsuren, A, Hoffmann, E	Biophys Chem	2002
18287102	Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain Lau, J, Rudolph, R, Madsen, K, Thøgersen, H, Runge, S	J Biol Chem	2008
19861722	Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor Peters, GH, Knudsen, LB, Reedtz-Runge, S, Rudolph, R, Underwood, CR, Hastrup, S, Garibay, P	J Biol Chem	2009
8405712	Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor Morel, P, Widmann, C, Thorens, B, Porret, A, Buhler, L, Deng, SP	Diabetes	1993
8138058	Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans Orskov, C, Rabenhøj, L, Kofod, H, Wettergren, A, Holst, JJ	Diabetes	1994
17306374	Mechanisms of action of glucagon-like peptide 1 in the pancreas Egan, JM, Doyle, ME	Pharmacol Ther	2007
17444618	Differential structural properties of GLP-1 and exendin-4 determine their relative affinity for the GLP-1 receptor N-terminal extracellular domain Lau, J, Schimmer, S, Rudolph, R, Madsen, K, Schiødt, CB, Thøgersen, H, Jeppesen, CB, Runge, S, Knudsen, SM, Oschmann, J	Biochemistry	2007