Reactome | IGFBP4 binds IGF forming IGF:IGFBP4

IGFBP4 binds IGF forming IGF:IGFBP4

Stable Identifier

R-HSA-381543

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

IGFBP 4 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 4.

Literature References

PubMed ID	Title	Journal	Year
8781553	Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography Rechler, MM, Bach, LA	Biochim Biophys Acta	1996
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
12466191	Cellular actions of the insulin-like growth factor binding proteins Baxter, RC, Firth, SM	Endocr Rev	2002
15642270	Structural basis for the regulation of insulin-like growth factors by IGF binding proteins Lang, K, Kuenkele, KP, Siwanowicz, I, Holak, TA, Huber, R, Popowicz, GM, Wisniewska, M, Engh, RA	Structure	2005
7683646	Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 Hsieh, S, Sakano, K, Rechler, MM, Fujiwara, H, Bach, LA, Perdue, JF	J Biol Chem	1993
7519608	Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes Arai, T, Busby W, Jr, Parker, A, Clemmons, DR	J Biol Chem	1994
17047378	The role of insulin-like growth factor binding proteins Perks, C, Holly, J	Neuroendocrinology	2006
7689487	Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting Savage, MO, Holly, JM, Frost, VJ, Cianfarani, S	Experientia	1993
12904166	IGF-binding protein-4: biochemical characteristics and functional consequences Wolf, E, Lahm, H, Zhou, R, Hoeflich, A, Diehl, D	J Endocrinol	2003