IGFBP4 binds IGF forming IGF:IGFBP4

Stable Identifier
R-HSA-381543
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IGFBP 4 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 4.

Literature References
PubMed ID Title Journal Year
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
7683646 Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

Bach, LA, Hsieh, S, Sakano, K, Fujiwara, H, Perdue, JF, Rechler, MM

J Biol Chem 1993
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
15642270 Structural basis for the regulation of insulin-like growth factors by IGF binding proteins

Siwanowicz, I, Popowicz, GM, Wisniewska, M, Huber, R, Kuenkele, KP, Lang, K, Engh, RA, Holak, TA

Structure 2005
7689487 Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Cianfarani, S, Frost, VJ, Savage, MO, Holly, JM

Experientia 1993
8781553 Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography

Bach, LA, Rechler, MM

Biochim Biophys Acta 1996
7519608 Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes

Arai, T, Parker, A, Busby W, Jr, Clemmons, DR

J Biol Chem 1994
12904166 IGF-binding protein-4: biochemical characteristics and functional consequences

Zhou, R, Diehl, D, Hoeflich, A, Lahm, H, Wolf, E

J Endocrinol 2003
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