IGFBP6 binds IGF forming IGF:IGFBP6

Stable Identifier
Reaction [binding]
Homo sapiens
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IGFBP-6 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP-6. IGFBP-6 binds IGF II with greater affinity than IGF I.
Literature References
PubMed ID Title Journal Year
7683646 Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

Hsieh, S, Sakano, K, Rechler, MM, Fujiwara, H, Bach, LA, Perdue, JF

J Biol Chem 1993
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
15525596 Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding

Leeding, KS, Headey, SJ, Norton, RS, Bach, LA

J Mol Endocrinol 2004
15308688 C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II

Brasier, G, Headey, SJ, Norton, RS, Bach, LA, Kantharidis, P, Yao, S, Keizer, DW

Mol Endocrinol 2004
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
7689487 Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Savage, MO, Holly, JM, Frost, VJ, Cianfarani, S

Experientia 1993
8781553 Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography

Rechler, MM, Bach, LA

Biochim Biophys Acta 1996
7525263 Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts

Hsieh, S, Brown, AL, Rechler, MM, Bach, LA

Endocrinology 1994
10951195 O-glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysis

Neumann, GM, Marinaro, JA, Leeding, KS, Russo, VC, Bach, LA

Eur J Biochem 2000
Orthologous Events
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