Reactome | IGFBP6 binds IGF forming IGF:IGFBP6

IGFBP6 binds IGF forming IGF:IGFBP6

Stable Identifier

R-HSA-381503

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

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IGFBP-6 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP-6. IGFBP-6 binds IGF II with greater affinity than IGF I.

Literature References

PubMed ID	Title	Journal	Year
12466191	Cellular actions of the insulin-like growth factor binding proteins Firth, SM, Baxter, RC	Endocr Rev	2002
7683646	Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 Bach, LA, Hsieh, S, Sakano, K, Fujiwara, H, Perdue, JF, Rechler, MM	J Biol Chem	1993
17047378	The role of insulin-like growth factor binding proteins Holly, J, Perks, C	Neuroendocrinology	2006
15525596	Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding Headey, SJ, Leeding, KS, Norton, RS, Bach, LA	J Mol Endocrinol	2004
15308688	C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II Headey, SJ, Keizer, DW, Yao, S, Brasier, G, Kantharidis, P, Bach, LA, Norton, RS	Mol Endocrinol	2004
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
7689487	Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting Cianfarani, S, Frost, VJ, Savage, MO, Holly, JM	Experientia	1993
8781553	Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography Bach, LA, Rechler, MM	Biochim Biophys Acta	1996
7525263	Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts Bach, LA, Hsieh, S, Brown, AL, Rechler, MM	Endocrinology	1994
10951195	O-glycosylation of insulin-like growth factor (IGF) binding protein-6 maintains high IGF-II binding affinity by decreasing binding to glycosaminoglycans and susceptibility to proteolysis Marinaro, JA, Neumann, GM, Russo, VC, Leeding, KS, Bach, LA	Eur J Biochem	2000