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IGFBP5(164-272) [extracellular region]
Stable Identifier
R-HSA-381478
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IGFBP-5 (164-272 fragment)
Locations in the PathwayBrowser for interactor UniProt:Q9Y676 MRPS18B
Expand all
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)
IGFBP5(164-272) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24593 IGFBP5
Gene Names
IGFBP5, IBP5
Chain
signal peptide:1-20, chain:21-272
Reference Genes
BioGPS Gene:3488 IGFBP5
COSMIC (genes):IGFBP5 IGFBP5
CTD Gene:3488 IGFBP5
dbSNP Gene:3488 IGFBP5
ENSEMBL:ENSG00000115461 IGFBP5
ENSEMBL_homo_sapiens_GENE:ENSG00000115461.5 IGFBP5
HGNC:5474 IGFBP5
KEGG Gene (Homo sapiens):3488 IGFBP5
Monarch:3488 IGFBP5
NCBI Gene:3488 IGFBP5
OMIM:146734 IGFBP5
UCSC:P24593 IGFBP5
Reference Transcript
RefSeq:NM_000599.3 IGFBP5
Other Identifiers
11728653_at
11728654_x_at
11728655_at
11728656_at
11728657_at
11758196_s_at
1396_at
1555997_PM_s_at
1555997_s_at
1601_s_at
1677_at
1678_g_at
16908197
203424_PM_s_at
203424_s_at
203425_PM_s_at
203425_s_at
203426_PM_s_at
203426_s_at
211958_PM_at
211958_at
211959_3p_at
211959_PM_at
211959_at
2598821
2598823
2598825
2598827
2598829
2598830
2598831
2598832
2598833
2598834
2598835
2598836
2598837
2598839
2598850
2598851
3488
38650_at
41420_at
75124_s_at
78056_s_at
8058857
A_23_P154115
A_23_P376497
A_23_P383009
GE54521
GO:0001558
GO:0001649
GO:0001968
GO:0003012
GO:0005515
GO:0005520
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0007165
GO:0007565
GO:0014070
GO:0014912
GO:0016942
GO:0017148
GO:0019838
GO:0022414
GO:0023052
GO:0030154
GO:0030336
GO:0031069
GO:0031994
GO:0031995
GO:0035556
GO:0040008
GO:0042567
GO:0042593
GO:0043226
GO:0043567
GO:0043568
GO:0043569
GO:0044342
GO:0045668
GO:0045926
GO:0048009
GO:0048286
GO:0048662
GO:0048856
GO:0048870
GO:0050896
GO:0051146
GO:0051897
GO:0060056
GO:0060416
GO:0071320
GO:0071407
GO:1901862
GO:1904205
GO:1904707
GO:1904754
HMNXSV003027575
Hs.103391.0.A1_3p_at
Hs.103391.0.A2_3p_at
Hs.103391.0.A2_3p_s_at
Hs.107169.0.S1_3p_a_at
Hs2.427785.1.S1_3p_s_at
ILMN_1750324
ILMN_2132982
L27559_s_at
L27560_at
M62782_s_at
M65062_at
PH_hs_0018547
PH_hs_0026735
TC02002758.hg
g10834981_3p_a_at
g184819_3p_s_at
Participates
as an output of
PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)
Other forms of this molecule
IGFBP5 [endoplasmic reticulum lumen]
p-IGFBP5 [endoplasmic reticulum lumen]
IGFBP5 [extracellular region]
IGFBP5(21-163) [extracellular region]
Inferred To
Igfbp5 [extracellular region]
(Rattus norvegicus)
igfbp5a [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_000590.1
OpenTargets
ENSG00000115461
GeneCards
P24593
ZINC - Substances
IBP5_HUMAN
HPA
ENSG00000115461-IGFBP5
Ensembl
ENSP00000233813
,
ENST00000233813
,
ENSG00000115461
ZINC target
P24593
PRO
P24593
Pharos - Targets
P24593
PDB
1H59
,
1BOE
,
7UFG
Interactors (72)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O43889-2 CREB3
0.666
4
UniProt:Q9H2H9 SLC38A1
1
SLC38A1 [plasma membrane]
(R-HSA-212663)
0.601
4
UniProt:Q6ZS10 CL17A
0.601
4
UniProt:Q8WZ55 BSND
1
BSND [plasma membrane]
(R-HSA-2854996)
0.556
3
UniProt:Q9NPE6 SPAG4
0.556
3
UniProt:Q5T700 LRAD1
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q6UX15-2 Q6UX152
0.556
3
UniProt:P48165 GJA8
1
GJA8 [endoplasmic reticulum membrane]
(R-HSA-190702)
0.556
3
UniProt:Q86WI0 LHPL1
0.556
3
UniProt:Q9UBD6 RHCG
1
RHCG [plasma membrane]
(R-HSA-444397)
0.556
3
UniProt:Q8TDT2 GP152
0.556
3
UniProt:Q96A25 T106A
0.556
3
UniProt:Q5TGU0 TSPO2
0.556
3
UniProt:Q9NZD1 GPC5D
0.556
3
UniProt:Q6IBW4-4 NCAPH2
0.556
3
UniProt:P36382 GJA5
1
GJA5 [endoplasmic reticulum membrane]
(R-HSA-190648)
0.556
3
UniProt:Q9Y320 TMX2
0.556
3
UniProt:Q8NBJ4 GOLM1
2
p-GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956938)
GOLM1 [endoplasmic reticulum lumen]
(R-HSA-8956710)
0.556
3
UniProt:Q8N205-2 SYNE4
0.556
3
UniProt:Q9NYP7 ELOVL5
1
ELOVL5 [endoplasmic reticulum membrane]
(R-HSA-548679)
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:Q8NFJ6 PROKR2
1
PROKR2 [plasma membrane]
(R-HSA-444637)
0.556
3
UniProt:O95377 GJB5
1
GJB5 [endoplasmic reticulum membrane]
(R-HSA-190643)
0.556
3
UniProt:Q9GZW8 MS4A7
0.556
3
UniProt:Q4KMG9 TM52B
0.556
3
UniProt:Q96BI3 APH1A
2
APH1A [endosome membrane]
(R-HSA-9010105)
APH1A [plasma membrane]
(R-HSA-3211581)
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:Q8IVF2-3 AHNAK2
0.556
3
UniProt:P56747 CLDN6
2
CLDN6 [plasma membrane]
(R-HSA-419992)
CLDN6 [cell junction]
(R-HSA-421250)
0.556
3
UniProt:P19397 CD53
3
CD53 [specific granule membrane]
(R-HSA-6804793)
CD53 [plasma membrane]
(R-HSA-6804817)
CD53 [tertiary granule membrane]
(R-HSA-6804799)
0.556
3
UniProt:Q9UKG4 SLC13A4
1
SLC13A4 [plasma membrane]
(R-HSA-433098)
0.556
3
UniProt:O95859 TSN12
0.556
3
UniProt:P25024 CXCR1
2
CXCR1 [secretory granule membrane]
(R-HSA-6804780)
CXCR1 [plasma membrane]
(R-HSA-373805)
0.556
3
UniProt:Q8TB40 ABHD4
1
ABHD4 [endoplasmic reticulum membrane]
(R-HSA-5694582)
0.556
3
UniProt:Q8IYS2 K2013
0.556
3
UniProt:Q9NWC5 TM45A
0.556
3
UniProt:Q68DC2 ANKS6
0.556
3
UniProt:Q96HJ5 MS4A3
2
MS4A3 [plasma membrane]
(R-HSA-6806321)
MS4A3 [specific granule membrane]
(R-HSA-6799514)
0.556
3
UniProt:O75712 GJB3
2
GJB3 [plasma membrane]
(R-HSA-9839595)
GJB3 [endoplasmic reticulum membrane]
(R-HSA-190625)
0.556
3
UniProt:Q86WK6 AMGO1
0.556
3
UniProt:O95484 CLDN9
2
CLDN9 [plasma membrane]
(R-HSA-420016)
CLDN9 [cell junction]
(R-HSA-421271)
0.556
3
UniProt:Q8WY91 THAP4
0.556
3
UniProt:Q86VI4 LAP4B
0.556
3
UniProt:Q8TBE3 FNDC9
0.556
3
UniProt:Q9H9P2 CHODL
0.556
3
UniProt:P57739 CLDN2
2
CLDN2 [plasma membrane]
(R-HSA-419994)
CLDN2 [cell junction]
(R-HSA-421235)
0.556
3
UniProt:P41181 AQP2
3
AQP2 [transport vesicle membrane]
(R-HSA-432215)
p-S256-AQP2 [transport vesicle membrane]
(R-HSA-432222)
p-S256-AQP2 [plasma membrane]
(R-HSA-432231)
0.556
3
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:Q7Z7N9 TMEM179B
4
TMEM179B [ficolin-1-rich granule membrane]
(R-HSA-6800989)
TMEM179B [secretory granule membrane]
(R-HSA-6801009)
TMEM179B [plasma membrane]
(R-HSA-6806263)
TMEM179B [azurophil granule membrane]
(R-HSA-6799362)
0.556
3
UniProt:Q96JW4 SLC41A2
1
SLC41A2 [plasma membrane]
(R-HSA-442666)
0.556
3
UniProt:O43315 AQP9
1
AQP9 [plasma membrane]
(R-HSA-431761)
0.556
3
UniProt:Q8TDV0 GP151
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:P07306 ASGR1
1
PALM-C36-ASGR1 [plasma membrane]
(R-HSA-8855714)
0.556
3
UniProt:O15529 GPR42
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:O95471 CLDN7
2
CLDN7 [cell junction]
(R-HSA-421241)
CLDN7 [plasma membrane]
(R-HSA-420004)
0.556
3
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:Q3KNW5 SLC10A6
1
SLC10A6 [plasma membrane]
(R-HSA-433091)
0.556
3
UniProt:Q9BVX2 T106C
0.556
3
UniProt:Q9HA82 CERS4
1
CERS4 [endoplasmic reticulum membrane]
(R-HSA-428138)
0.556
3
UniProt:O60883 GPR37L1
1
GPR37L1 [plasma membrane]
(R-HSA-5336178)
0.556
3
UniProt:P56880 CLDN20
2
CLDN20 [plasma membrane]
(R-HSA-432974)
CLDN20 [cell junction]
(R-HSA-434611)
0.556
3
UniProt:Q9Y676 MRPS18B
1
MRPS18B [mitochondrial inner membrane]
(R-HSA-5368234)
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q96P31-6 Q96P316
0.556
3
UniProt:Q96GZ6 S41A3
0.556
3
UniProt:O15393-2 TMPRSS2
0.556
3
UniProt:Q96MV1 TLCD4
0.556
3
UniProt:Q96Q45-2 TMEM237
0.556
5
UniProt:O95279 KCNK5
1
KCNK5 [plasma membrane]
(R-HSA-1296323)
0.556
3
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