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IGFBP6 [extracellular region]
Stable Identifier
R-HSA-381475
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Insulin-like Growth Factor Binding Protein-6, IBP6_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q96SQ5 ZNF587
Expand all
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)
IGFBP6 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24592 IGFBP6
Gene Names
IGFBP6, IBP6
Chain
signal peptide:1-27, chain:28-240
Reference Genes
BioGPS Gene:3489 IGFBP6
COSMIC (genes):IGFBP6 IGFBP6
CTD Gene:3489 IGFBP6
dbSNP Gene:3489 IGFBP6
ENSEMBL:ENSG00000167779 IGFBP6
ENSEMBL_homo_sapiens_GENE:ENSG00000167779.9 IGFBP6
HGNC:5475 IGFBP6
KEGG Gene (Homo sapiens):3489 IGFBP6
Monarch:3489 IGFBP6
NCBI Gene:3489 IGFBP6
OMIM:146735 IGFBP6
UCSC:P24592 IGFBP6
Reference Transcript
RefSeq:NM_002178.2 IGFBP6
Other Identifiers
11717909_at
16751655
1736_at
203851_PM_at
203851_at
3415750
3415751
3415752
3415753
3415755
3415756
3415758
3415759
3415760
3489
7955694
A_23_P139912
GE79606
GO:0001968
GO:0005102
GO:0005515
GO:0005520
GO:0005576
GO:0005615
GO:0007165
GO:0008285
GO:0016477
GO:0019838
GO:0023052
GO:0031994
GO:0031995
GO:0032874
GO:0042568
GO:0042802
GO:0043410
GO:0043567
GO:0048870
GO:0090090
ILMN_1669362
M62402_at
PH_hs_0014144
TC12000428.hg
g11321592_3p_at
Participates
as a component of
IGF:IGFBP6 [extracellular region] (Homo sapiens)
as an input of
IGFBP6 binds IGF forming IGF:IGFBP6 (Homo sapiens)
Inferred To
Igfbp6 [extracellular region]
(Mus musculus)
Igfbp6 [extracellular region]
(Rattus norvegicus)
igfbp6a [extracellular region]
(Danio rerio)
IGFBP6 [extracellular region]
(Bos taurus)
IGFBP6 [extracellular region]
(Canis familiaris)
IGFBP6 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_002169.1
OpenTargets
ENSG00000167779
HPA
ENSG00000167779-IGFBP6
GeneCards
P24592
ZINC - Substances
IBP6_HUMAN
ZINC target
P24592
Ensembl
ENSG00000167779
,
ENST00000301464
,
ENSP00000301464
PRO
P24592
Pharos - Targets
P24592
PDB
1RMJ
,
2JM2
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:O95983-2 MBD3
0.556
3
UniProt:Q6IQ23-2 PLEKHA7
0.556
3
UniProt:P24592 IGFBP6
1
IGFBP6 [extracellular region]
(R-HSA-381475)
0.556
3
UniProt:Q96LT6 CA074
0.556
3
UniProt:O14770-4 MEIS2
0.556
3
UniProt:O95967 EFEMP2
1
EFEMP2 [extracellular region]
(R-HSA-2161231)
0.556
3
UniProt:Q7Z6N9 Q7Z6N9
0.556
3
UniProt:Q8IYX3 CC116
0.556
3
UniProt:Q9BSL1 UBAC1
1
UBAC1 [cytosol]
(R-HSA-8851644)
0.556
3
UniProt:Q12805 EFEMP1
1
EFEMP1 [extracellular region]
(R-HSA-2161393)
0.556
3
UniProt:P29972 AQP1
1
AQP1 [plasma membrane]
(R-HSA-431700)
0.556
3
UniProt:P49901 MCSP
0.556
3
UniProt:O14735 CDIPT
1
CDIPT [endoplasmic reticulum membrane]
(R-HSA-1498749)
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:P53611 RABGGTB
2
RABGGTB [plasma membrane]
(R-HSA-6801098)
RABGGTB [cytosol]
(R-HSA-8870419)
0.556
3
UniProt:A6NI15 MSGN1
1
MSGN1 [nucleoplasm]
(R-HSA-9793376)
0.556
3
UniProt:Q6VN20 RANBP10
1
RANBP10 [cytosol]
(R-HSA-8851865)
0.556
3
UniProt:O43681 GET3
1
ASNA1 [cytosol]
(R-HSA-9609520)
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
5
UniProt:X5D778 X5D778
0.556
3
UniProt:Q9UM22 EPDR1
0.556
3
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.556
3
UniProt:Q02930-3 CREB5
0.556
3
UniProt:Q6L8G8 KRTAP5-7
1
KRTAP5-7 [cytosol]
(R-HSA-6810273)
0.556
3
UniProt:Q9H0I2 ENKD1
0.556
3
UniProt:P05187 ALPP
1
ALPP [transport vesicle]
(R-HSA-8847823)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P61601 NCALD
1
NCALD [cytosol]
(R-HSA-450887)
0.556
3
UniProt:Q96SQ5 ZNF587
1
ZNF587 [nucleoplasm]
(R-HSA-2127565)
0.556
3
UniProt:P63098 PPP3R1
2
PPP3R1 [nucleoplasm]
(R-HSA-2685631)
PPP3R1 [cytosol]
(R-HSA-51291)
0.527
3
UniProt:P48454 PPP3CC
1
PPP3CC [cytosol]
(R-HSA-61113)
0.527
3
UniProt:A6NFQ2 TCAF2
0.527
3
UniProt:Q9BT73 PSMG3
1
PSMG3 [cytosol]
(R-HSA-9908033)
0.527
2
UniProt:Q9NRR5 UBQL4
0.488
2
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