Reactome | IGFBP6 [extracellular region]

IGFBP6 [extracellular region]

Stable Identifier

R-HSA-381475

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Insulin-like Growth Factor Binding Protein-6, IBP6_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O95967 EFEMP2

Expand all

External Reference Information

External Reference

UniProt:P24592 IGFBP6

Gene Names

IGFBP6, IBP6

Chain

signal peptide:1-27, chain:28-240

Reference Genes

BioGPS Gene:3489 IGFBP6

COSMIC (genes):IGFBP6 IGFBP6

CTD Gene:3489 IGFBP6

dbSNP Gene:3489 IGFBP6

ENSEMBL:ENSG00000167779 IGFBP6

HGNC:5475 IGFBP6

KEGG Gene (Homo sapiens):3489 IGFBP6

Monarch:3489 IGFBP6

NCBI Gene:3489 IGFBP6

OMIM:146735 IGFBP6

UCSC:P24592 IGFBP6

Reference Transcript

RefSeq:NM_002178.2 IGFBP6

Other Identifiers

0006290594

11717909_at

16751655

1736_at

203851_at

3415750

3415751

3415752

3415753

3415755

3415756

3415758

3415759

3415760

3489

7955694

A_23_P139912

GE79606

GO:0000187

GO:0001968

GO:0003674

GO:0005102

GO:0005515

GO:0005520

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005794

GO:0006464

GO:0007165

GO:0007267

GO:0008150

GO:0008283

GO:0008285

GO:0016477

GO:0019838

GO:0031994

GO:0031995

GO:0032991

GO:0040011

GO:0042568

GO:0042802

GO:0043226

GO:0043567

GO:0044267

GO:0048870

GO:0090090

ILMN_1669362

M62402_at

PH_hs_0014144

TC12000428.hg

g11321592_3p_at

Participant Of

hasComponent

IGF:IGFBP6 [extracellular region]

input

IGFBP6 binds IGF forming IGF:IGFBP6

Inferred To

Homologues of IGFBP6 [extracellular region] (Danio rerio)

Igfbp6 [extracellular region] (Mus musculus)

Igfbp6 [extracellular region] (Rattus norvegicus)

igfbp6b [extracellular region] (Danio rerio)

igfbp6a [extracellular region] (Danio rerio)

IGFBP6 [extracellular region] (Canis familiaris)

IGFBP6 [extracellular region] (Gallus gallus)

igfbp3 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_002169.1

OpenTargets

ENSG00000167779

ZINC - Substances

IBP6_HUMAN

GeneCards

P24592

HPA

ENSG00000167779-IGFBP6

ZINC target

P24592

Ensembl

ENSG00000167779, ENSP00000301464, ENST00000301464

PRO

P24592

PDB

1RMJ

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:O95983-2 MBD3			0.556	3
UniProt:Q6IQ23-2 PLEKHA7			0.556	3
UniProt:P24592 IGFBP6	1	IGFBP6 [extracellular region] (R-HSA-381475)	0.556	3
UniProt:Q96LT6 CA074			0.556	3
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:O14770-4 MEIS2			0.556	3
UniProt:Q7Z6N9 Q7Z6N9			0.556	3
UniProt:Q8IYX3 CC116			0.556	3
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.556	3
UniProt:Q12805 EFEMP1	1	EFEMP1 [extracellular region] (R-HSA-2161393)	0.556	3
UniProt:Q12837 POU4F2	1	POU4F2 [nucleoplasm] (R-HSA-6804414)	0.556	3
UniProt:P53611 RABGGTB	2	RABGGTB [plasma membrane] (R-HSA-6801098) RABGGTB [cytosol] (R-HSA-8870419)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q6VN20 RANBP10	1	RANBP10 [cytosol] (R-HSA-8851865)	0.556	3
UniProt:O43681 GET3	1	ASNA1 [cytosol] (R-HSA-9609520)	0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	5
UniProt:X5D778 X5D778			0.556	3
UniProt:Q9UM22 EPDR1			0.556	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q6L8G8 KRTAP5-7	1	KRTAP5-7 [cytosol] (R-HSA-6810273)	0.556	3
UniProt:Q02930-3 CREB5			0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:P05187 ALPP	1	ALPP [transport vesicle] (R-HSA-8847823)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P61601 NCALD	1	NCALD [cytosol] (R-HSA-450887)	0.556	3
UniProt:Q96SQ5 ZNF587	1	ZNF587 [nucleoplasm] (R-HSA-2127565)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:O14735 CDIPT	1	CDIPT [endoplasmic reticulum membrane] (R-HSA-1498749)	0.556	3
UniProt:P49901 MCSP			0.556	3
UniProt:A6NI15 MSGN1			0.556	3
UniProt:P29972 AQP1	1	AQP1 [plasma membrane] (R-HSA-431700)	0.556	3
UniProt:Q9NRR5 UBQL4			0.488	2

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