Reactome | IGFBP5 [extracellular region]

IGFBP5 [extracellular region]

Stable Identifier

R-HSA-381414

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Insulin-like Growth Factor Binding Protein-5, IBP5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y676 MRPS18B

Expand all

External Reference Information

External Reference

UniProt:P24593 IGFBP5

Gene Names

IGFBP5, IBP5

Chain

signal peptide:1-20, chain:21-272

Reference Genes

BioGPS Gene:3488 IGFBP5

COSMIC (genes):IGFBP5 IGFBP5

CTD Gene:3488 IGFBP5

dbSNP Gene:3488 IGFBP5

ENSEMBL:ENSG00000115461 IGFBP5

ENSEMBL_homo_sapiens_GENE:ENSG00000115461.5 IGFBP5

HGNC:5474 IGFBP5

KEGG Gene (Homo sapiens):3488 IGFBP5

Monarch:3488 IGFBP5

NCBI Gene:3488 IGFBP5

OMIM:146734 IGFBP5

UCSC:P24593 IGFBP5

Reference Transcript

RefSeq:NM_000599.3 IGFBP5

Other Identifiers

11728653_at

11728654_x_at

11728655_at

11728656_at

11728657_at

11758196_s_at

1396_at

1555997_PM_s_at

1555997_s_at

1601_s_at

1677_at

1678_g_at

16908197

203424_PM_s_at

203424_s_at

203425_PM_s_at

203425_s_at

203426_PM_s_at

203426_s_at

211958_PM_at

211958_at

211959_3p_at

211959_PM_at

211959_at

2598821

2598823

2598825

2598827

2598829

2598830

2598831

2598832

2598833

2598834

2598835

2598836

2598837

2598839

2598850

2598851

3488

38650_at

41420_at

75124_s_at

78056_s_at

8058857

A_23_P154115

A_23_P376497

A_23_P383009

GE54521

GO:0001558

GO:0001649

GO:0001968

GO:0003012

GO:0005515

GO:0005520

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0007165

GO:0007565

GO:0014070

GO:0014912

GO:0016942

GO:0017148

GO:0019838

GO:0022414

GO:0023052

GO:0030154

GO:0030336

GO:0031069

GO:0031994

GO:0031995

GO:0035556

GO:0040008

GO:0042567

GO:0042593

GO:0043226

GO:0043567

GO:0043568

GO:0043569

GO:0044342

GO:0045668

GO:0045926

GO:0048009

GO:0048286

GO:0048662

GO:0048856

GO:0048870

GO:0050896

GO:0051146

GO:0051897

GO:0060056

GO:0060416

GO:0071320

GO:0071407

GO:1901862

GO:1904205

GO:1904707

GO:1904754

HMNXSV003027575

Hs.103391.0.A1_3p_at

Hs.103391.0.A2_3p_at

Hs.103391.0.A2_3p_s_at

Hs.107169.0.S1_3p_a_at

Hs2.427785.1.S1_3p_s_at

ILMN_1750324

ILMN_2132982

L27559_s_at

L27560_at

M62782_s_at

M65062_at

PH_hs_0018547

PH_hs_0026735

TC02002758.hg

g10834981_3p_a_at

g184819_3p_s_at

Participates

as a component of

IGF:IGFBP5:ALS [extracellular region] (Homo sapiens)

as an input of

Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)

Other forms of this molecule

IGFBP5 [endoplasmic reticulum lumen]

p-IGFBP5 [endoplasmic reticulum lumen]

IGFBP5(21-163) [extracellular region]

IGFBP5(164-272) [extracellular region]

Inferred To

Igfbp5 [extracellular region] (Rattus norvegicus)

igfbp5a [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_000590.1

OpenTargets

ENSG00000115461

GeneCards

P24593

ZINC - Substances

IBP5_HUMAN

HPA

ENSG00000115461-IGFBP5

Ensembl

ENSP00000233813, ENST00000233813, ENSG00000115461

ZINC target

P24593

PRO

P24593

Pharos - Targets

P24593

PDB

1H59, 1BOE, 7UFG

Interactors (72)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43889-2 CREB3			0.666	4
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.601	4
UniProt:Q6ZS10 CL17A			0.601	4
UniProt:Q8WZ55 BSND	1	BSND [plasma membrane] (R-HSA-2854996)	0.556	3
UniProt:Q9NPE6 SPAG4			0.556	3
UniProt:Q5T700 LRAD1			0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q6UX15-2 Q6UX152			0.556	3
UniProt:P48165 GJA8	1	GJA8 [endoplasmic reticulum membrane] (R-HSA-190702)	0.556	3
UniProt:Q86WI0 LHPL1			0.556	3
UniProt:Q9UBD6 RHCG	1	RHCG [plasma membrane] (R-HSA-444397)	0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:Q96A25 T106A			0.556	3
UniProt:Q5TGU0 TSPO2			0.556	3
UniProt:Q9NZD1 GPC5D			0.556	3
UniProt:Q6IBW4-4 NCAPH2			0.556	3
UniProt:P36382 GJA5	1	GJA5 [endoplasmic reticulum membrane] (R-HSA-190648)	0.556	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:Q8N205-2 SYNE4			0.556	3
UniProt:Q9NYP7 ELOVL5	1	ELOVL5 [endoplasmic reticulum membrane] (R-HSA-548679)	0.556	3
UniProt:Q6N075 MFSD5			0.556	3
UniProt:Q8NFJ6 PROKR2	1	PROKR2 [plasma membrane] (R-HSA-444637)	0.556	3
UniProt:O95377 GJB5	1	GJB5 [endoplasmic reticulum membrane] (R-HSA-190643)	0.556	3
UniProt:Q9GZW8 MS4A7			0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:Q96BI3 APH1A	2	APH1A [endosome membrane] (R-HSA-9010105) APH1A [plasma membrane] (R-HSA-3211581)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:Q8IVF2-3 AHNAK2			0.556	3
UniProt:P56747 CLDN6	2	CLDN6 [plasma membrane] (R-HSA-419992) CLDN6 [cell junction] (R-HSA-421250)	0.556	3
UniProt:P19397 CD53	3	CD53 [specific granule membrane] (R-HSA-6804793) CD53 [plasma membrane] (R-HSA-6804817) CD53 [tertiary granule membrane] (R-HSA-6804799)	0.556	3
UniProt:Q9UKG4 SLC13A4	1	SLC13A4 [plasma membrane] (R-HSA-433098)	0.556	3
UniProt:O95859 TSN12			0.556	3
UniProt:P25024 CXCR1	2	CXCR1 [secretory granule membrane] (R-HSA-6804780) CXCR1 [plasma membrane] (R-HSA-373805)	0.556	3
UniProt:Q8TB40 ABHD4	1	ABHD4 [endoplasmic reticulum membrane] (R-HSA-5694582)	0.556	3
UniProt:Q8IYS2 K2013			0.556	3
UniProt:Q9NWC5 TM45A			0.556	3
UniProt:Q68DC2 ANKS6			0.556	3
UniProt:Q96HJ5 MS4A3	2	MS4A3 [plasma membrane] (R-HSA-6806321) MS4A3 [specific granule membrane] (R-HSA-6799514)	0.556	3
UniProt:O75712 GJB3	2	GJB3 [plasma membrane] (R-HSA-9839595) GJB3 [endoplasmic reticulum membrane] (R-HSA-190625)	0.556	3
UniProt:Q86WK6 AMGO1			0.556	3
UniProt:O95484 CLDN9	2	CLDN9 [plasma membrane] (R-HSA-420016) CLDN9 [cell junction] (R-HSA-421271)	0.556	3
UniProt:Q8WY91 THAP4			0.556	3
UniProt:Q86VI4 LAP4B			0.556	3
UniProt:Q8TBE3 FNDC9			0.556	3
UniProt:Q9H9P2 CHODL			0.556	3
UniProt:P57739 CLDN2	2	CLDN2 [plasma membrane] (R-HSA-419994) CLDN2 [cell junction] (R-HSA-421235)	0.556	3
UniProt:P41181 AQP2	3	AQP2 [transport vesicle membrane] (R-HSA-432215) p-S256-AQP2 [transport vesicle membrane] (R-HSA-432222) p-S256-AQP2 [plasma membrane] (R-HSA-432231)	0.556	3
UniProt:Q9GZY8-5 MFF			0.556	3
UniProt:Q7Z7N9 TMEM179B	4	TMEM179B [ficolin-1-rich granule membrane] (R-HSA-6800989) TMEM179B [secretory granule membrane] (R-HSA-6801009) TMEM179B [plasma membrane] (R-HSA-6806263) TMEM179B [azurophil granule membrane] (R-HSA-6799362)	0.556	3
UniProt:Q96JW4 SLC41A2	1	SLC41A2 [plasma membrane] (R-HSA-442666)	0.556	3
UniProt:O43315 AQP9	1	AQP9 [plasma membrane] (R-HSA-431761)	0.556	3
UniProt:Q8TDV0 GP151			0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:P07306 ASGR1	1	PALM-C36-ASGR1 [plasma membrane] (R-HSA-8855714)	0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:O95471 CLDN7	2	CLDN7 [cell junction] (R-HSA-421241) CLDN7 [plasma membrane] (R-HSA-420004)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q9BVX2 T106C			0.556	3
UniProt:Q9HA82 CERS4	1	CERS4 [endoplasmic reticulum membrane] (R-HSA-428138)	0.556	3
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:P56880 CLDN20	2	CLDN20 [plasma membrane] (R-HSA-432974) CLDN20 [cell junction] (R-HSA-434611)	0.556	3
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:Q96P31-6 Q96P316			0.556	3
UniProt:Q96GZ6 S41A3			0.556	3
UniProt:O15393-2 TMPRSS2			0.556	3
UniProt:Q96MV1 TLCD4			0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	5
UniProt:O95279 KCNK5	1	KCNK5 [plasma membrane] (R-HSA-1296323)	0.556	3

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